synthesis of new imidazolidin-2,4-dione and 2-thioxoimidazolidin-4-ones via c-phenylglycine derivatives合成新的imidazolidin-2 4-dione并通过c-phenylglycine 2-thioxoimidazolidin-4-ones衍生品.pdfVIP

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synthesis of new imidazolidin-2,4-dione and 2-thioxoimidazolidin-4-ones via c-phenylglycine derivatives合成新的imidazolidin-2 4-dione并通过c-phenylglycine 2-thioxoimidazolidin-4-ones衍生品.pdf

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synthesis of new imidazolidin-2,4-dione and 2-thioxoimidazolidin-4-ones via c-phenylglycine derivatives合成新的imidazolidin-2 4-dione并通过c-phenylglycine 2-thioxoimidazolidin-4-ones衍生品

Molecules 2010, 15, 128-137; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Synthesis of New Imidazolidin-2,4-dione and 2-Thioxo- imidazolidin-4-ones via C-Phenylglycine Derivatives José Alixandre de Sousa Luis 1,2, José Maria Barbosa Filho 1, Bruno Freitas Lira 1, Isac Almeida 1 1 3 Medeiros , Liana Clébia Soares Lima de Morais , Alexsandro Fernandes dos Santos , Cledualdo Soares de Oliveira 3 and Petrônio Filgueiras de Athayde-Filho 1,3,* 1 Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, João Pessoa - PB, CEP 58.051-970, Brazil 2 Centro de Educação e Saúde, Unidade Acadêmica de Saúde, Universidade Federal de Campina Grande, Cuité - PB, CEP 58.175-000, Brazil 3 Departamento de Química, Universidade Federal da Paraíba, Campus I, João Pessoa - PB, CEP 58059-900, Brazil * Author to whom correspondence should be addressed; E-Mail: athayde-filho@quimica.ufpb.br. Received: 13 October 2009; in revised form: 1 December 2009 / Accepted: 2 December 2009 / Published: 30 December 2009 Abstract: Hydantoins and their derivatives constitute a group of pharmaceutical compounds with anticonvulsant and antiarrhythmic properties, and are also used against diabetes. N-3 and C-5 substituted imidazolidines are examples of such products. As such, we have developed a synthesis of 2,4-dione and 2-thioxo-4-one imidazolidinic derivatives by reaction of