survey of tyrosine kinase signaling reveals ros kinase fusions in human cholangiocarcinoma酪氨酸激酶信号传导的调查揭示了ros激酶融合在人类胆管癌.pdfVIP

Survey of Tyrosine Kinase Signaling Reveals ROS Kinase Fusions in Human Cholangiocarcinoma 1 . 2. 3. 1 1 Ting-Lei Gu * , Xiaxing Deng , Feizhou Huang , Meghan Tucker , Katherine Crosby , Victoria 1 1 3 3 4 4 4 1 Rimkunas , Yi Wang , Gang Deng , Lei Zhu , Zhiping Tan , Yerong Hu , Chunlin Wu , Julie Nardone , 1 1 1 1 1 1 1 Joan MacNeill , Jianmin Ren , Cynthia Reeves , Gregory Innocenti , Brett Norris , Jin Yuan , Jian Yu , 1 2 2 2 4 3 Herbert Haack , Baiyong Shen , Chenghong Peng , Hongwei Li , Xinmin Zhou , Xunyang Liu , John 1 1 Rush , Michael J. Comb * 1 Cell Signaling Technology, Danvers, Massachusetts, United States of America, 2 Center of Organ Transplantation, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 3 Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, China, 4 Department of Cardiothoracic Surgery, The Second Xiangya Hospital, Central South University, Changsha, China Abstract Cholangiocarcinoma, also known as bile duct cancer, is the second most common primary hepatic carcinoma with a median survival of less than 2 years. The molecular mechanisms underlying the development of this disease are not clear. To survey activated tyrosine kinases signaling in cholangiocarcinoma, we employed immunoaff