survival from xdr-tb is associated with modifiable clinical characteristics in rural south africa生存在农村广泛耐药结核与修改的临床特点南非.pdfVIP

Survival from XDR-TB Is Associated with Modifiable Clinical Characteristics in Rural South Africa 1 2 3 1 3,4 Sheela V. Shenoi *, Ralph P. Brooks , Russell Barbour , Frederick L. Altice , Daniel Zelterman , 5 6 5 1 Anthony P. Moll , Iqbal Master , Theo L. van der Merwe , Gerald H. Friedland 1 Department of Medicine, Section of Infectious Diseases, AIDS Program, Yale University, School of Medicine New Haven, Connecticut, United States of America, 2 Philanjalo Care Centre, Tugela Ferry, South Africa, 3 Center for Interdisciplinary Research on AIDS, Yale University, New Haven, Connecticut, United States of America, 4 Division of Biostatistics, Yale University School of Public Health, New Haven, Connecticut, United States of America, 5 Church of Scotland Hospital, Tugela Ferry, South Africa, 6 King George V Hospital, Durban, South Africa Abstract Background: Drug-resistant tuberculosis (TB) is a major threat to global public health. Patients with extensively drug- resistant TB (XDR-TB), particularly those with HIV-coinfection, experience high and accelerated mortality with limited available interventions. To determine modifiable factors associated with survival, we evaluated XDR-TB patients from a community-based hospital in rural South Africa where a large number of XDR-TB cases were first detected. Methodology/Principal Findings: A retrospective case control study was conducted of XDR-TB patients diagnosed from 2005–2008. Survivors, those alive at 180 days from diagnostic sputum collection date, were compared w