studies on carcinogenic and toxic effects of ochratoxin a in chicks研究致癌和小鸡赭曲霉毒素a的毒性作用.pdfVIP

下载本文档

1
0
约5.03万字
约 16页
2017-09-12 发布于上海
举报
版权申诉

studies on carcinogenic and toxic effects of ochratoxin a in chicks研究致癌和小鸡赭曲霉毒素a的毒性作用.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

studies on carcinogenic and toxic effects of ochratoxin a in chicks研究致癌和小鸡赭曲霉毒素a的毒性作用

Toxins 2010, 2, 649-664; doi:10.3390/toxins2040649 OPEN ACCESS toxins ISSN 2072-6651 /journal/toxins Article Studies on Carcinogenic and Toxic Effects of Ochratoxin A in Chicks Stoycho D. Stoev Department of General and Clinical Pathology, Faculty of Veterinary Medicine, Trakia University, Students campus, 6000 Stara Zagora, Bulgaria; E-Mail: stoev@uni-sz.bg; Tel.: +359-42-670-540; Fax: +359-42-670-624. Received: 25 February 2010; in revised form: 28 March 2010 / Accepted: 7 April 2010/ Published: 12 April 2010 Abstract: Carcinogenic/toxic effects of ochratoxin A (OTA) in various internal organs of Plymouth Rock chicks were determined. The number of OTA-induced neoplasms was similar in chicks given 25 ppm L--phenylalanine (PHE) in addition to 5 ppm OTA compared to chicks given only 5 ppm OTA, which showed that PHE cannot be used as a real protector against the carcinogenic or toxic effects of OTA in chicks. OTA was found to provoke strong degenerative changes in liver and kidneys, degenerative changes and depletion of cells in lymphoid organs, oedematous and degenerative changes in the brain, muscular haemorrhages and fatty changes in the bone marrow. The target organs for carcinogenic effect of OTA in chicks were found to be kidneys and liver. Keywords: ochratoxin A; phenylalanine; carcinogenic effect; chicks; pathology 1. Introduction Ochratoxin A (OTA) is a mycotoxin widely encountered in animal