sporadic haemangioblastoma of the kidney with rhabdoid features and focal cd10 expression report of a case and literature review肾脏的零星haemangioblastoma杆状的特性和焦cd10表达式案件报告和文献综述.pdfVIP

Yin et al. Diagnostic Pathology 2012, 7:39 /content/7/1/39 CASE REPORT Open Access Sporadic haemangioblastoma of the kidney with rhabdoid features and focal CD10 expression: report of a case and literature review 1 1* 2 Wei-hua Yin , Jian Li and John KC Chan Abstract We present here an intriguing case of sporadic renal haemangioblastoma occurring in a 61-year-old male. The tumor consisted of nests of polygonal cells and abundant capillary networks. The neoplastic cells generally showed abundant eosinophilic cytoplasm and prominent eccentric nuclei, resembling the rhabdoid cells. Pronounced intranuclear cytoplasmic pseudoinclusions were another significant feature seen. NSE, a-inhibin and S100 were positive in tumor cells and particularly, focal CD10 expressions were observed. This is possibly the first reported case of a haemangioblastoma showing a rhabdoid phenotype and CD10 immunopositivity. Malignant rhabdoid tumor and renal cell carcinoma with rhabdoid features were probably the most challenging mimics need to be differentiated. The result of focal CD10 staining in our case may further lead to confusion with renal cell carcinoma. To avoid misdiagnosis, more considerations should be attached to the rare neoplasm. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/1068858553657049 Keywords: Haemangioblastoma, Kidney, CD10, Rhabdoid features Background Case presentation Haemangioblastoma is a slowly growing, highly vascular A 61-year-old man was admitted to our hospital for a benign tumor, corresponding to WHO grade I. It typically solid mass found in the right kidney during a routine arises within th