soluble urokinase-type plasminogen activator receptor levels in patients with burn injuries and inhalation trauma requiring mechanical ventilation an observational cohort study可溶性urokinase-type烧伤患者纤溶酶原激活物受体水平和吸入创伤需要机械通风一个观察性队列研究.pdfVIP

Backes et al. Critical Care 2011, 15:R270 /content/15/6/R270 RESEARCH Open Access Soluble urokinase-type plasminogen activator receptor levels in patients with burn injuries and inhalation trauma requiring mechanical ventilation: an observational cohort study 1,2* 2 2 2,3 2,4 Yara Backes , Koenraad F van der Sluijs , Anita M Tuip de Boer , Jorrit Jan Hofstra , Alexander PJ Vlaar , 2,4 5 5 1,2 Rogier M Determann , Paul Knape , David P Mackie and Marcus J Schultz Abstract Introduction: Soluble urokinase-type plasminogen activator receptor (suPAR) has been proposed as a biologic marker of fibrinolysis and inflammation. The aim of this study was to investigate the diagnostic and prognostic value of systemic and pulmonary levels of suPAR in burn patients with inhalation trauma who need mechanical ventilation. Methods: suPAR was measured in plasma and nondirected lung-lavage fluid of mechanically ventilated burn patients with inhalation trauma. The samples were obtained on the day of inhalation trauma and on alternate days thereafter until patients were completely weaned from the mechanical ventilator. Mechanically ventilated patients without burns and without pulmonary disease served as controls. Results: Systemic levels of suPAR in burn patients with inhalation trauma were not different from those in control patients. On admission and follow up, pulmonary levels of suPAR in patients with inhalation trauma were significantly higher compared with controls. Pulmonary levels of suPAR highly correlated with pulmonary levels of interleukin 6, a marker of inflammation, and thr