solvent composition is critical for carbodiimide cross-linking of hyaluronic acid as an ophthalmic biomaterial溶剂成分是至关重要的碳化二亚胺交联透明质酸作为眼科生物材料.pdfVIP

下载本文档

2
0
约5.18万字
约 17页
2017-09-12 发布于上海
举报
版权申诉

solvent composition is critical for carbodiimide cross-linking of hyaluronic acid as an ophthalmic biomaterial溶剂成分是至关重要的碳化二亚胺交联透明质酸作为眼科生物材料.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

solvent composition is critical for carbodiimide cross-linking of hyaluronic acid as an ophthalmic biomaterial溶剂成分是至关重要的碳化二亚胺交联透明质酸作为眼科生物材料

Materials 2012, 5, 1986-2002; doi:10.3390/ma5101986 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article Solvent Composition is Critical for Carbodiimide Cross-Linking of Hyaluronic Acid as an Ophthalmic Biomaterial Jui-Yang Lai 1,2,3 1 Institute of Biochemical and Biomedical Engineering, Chang Gung University, Taoyuan 33302, Taiwan; E-Mail: jylai@.tw; Tel.: +886-3-211-8800, ext. 3598; Fax: +886-3-211-8668 2 Biomedical Engineering Research Center, Chang Gung University, Taoyuan 33302, Taiwan 3 Molecular Medicine Research Center, Chang Gung University, Taoyuan 33302, Taiwan Received: 11 October 2012; in revised form: 16 October 2012 / Accepted: 18 October 2012 / Published: 23 October 2012 Abstract: Hyaluronic acid (HA) is one of the most important ophthalmic biomaterials, while also being used for tissue engineering and drug delivery. Although chemical cross-linking is an effective way to improve the material performance, it may as a consequence be detrimental to the living cells/tissues. Given that the cross-linking efficiency is mediated by the solvent composition during the chemical modification, this study aims to explore the stability and biocompatibility of carbodiimide cross-linked HA in relation to material processing conditions by varying the acetone/water volume ratio (from 70:30 to 95:5) at a constant 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) concentration of 100 mM. Our