卡维地洛对猪急性心肌梗死再灌注后无再流影响.docVIP

卡维地洛对猪急性心肌梗死再灌注后无再流影响 　 作者：赵京林，杨跃进，荆志成,吴永建，尤士杰，杨伟宪，孟亮，田毅,陈纪林，高润林，陈在嘉 【关键词】 急性心肌梗死 Beneficial effects of carvedilol on myocardial noreflow in miniswine models of acute myocardial infarction and reperfusion 　　ZHAO JingLin, YANG YueJin, JING ZhiCheng, WU YongJian, YOU ShiJie, YANG WeiXian, MENG Liang, TIAN Yi, CHEN JiLin, GAO RunLin, CHEN ZaiJia 　　Department of Cardiovasology, Cardiovascular Institute, Fuwai Cardiovascular Disease Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China 　　【Abstract】 AIM: To evaluate the effects of carvedilol (beta blocker) on myocardial noreflow in a miniswine model of acute myocardial infarction (AMI) and reperfusion. METHODS: Twentyfour miniswine were randomized into 3 groups: control, carvediloltreatment ［1 mg/(kg#12539;d)］ and shamoperation groups (n=8). Animals in the former 2 groups were subjected to 3 h of coronary occlusion followed by 60 min of reperfusion. Data on hemodynamics and coronary blood flow volume (CBV) were collected and the area of noreflow (ANR) was evaluated with both myocardial contrast echocardiography (MCE) in vivo and pathological means. Necrosis area (NA) was measured with triphenyltetrazolium chloride (TTC) staining. RESULTS: ① In control group, left ventricular systolic pressure (LVSP), maximal rate of increase and decline in left ventricular pressure (±dp/dtmax) and cardiac output(CO) significantly declined (Plt;0.05), while pulmonary capillary wedge pressure (PCWP) and left ventricular enddiastolic pressure (LVEDP) significantly increased at the end of 3 h of left anterior descending (LAD) occlusion (Plt;0.01). Compared with those at the end of 3 h of occlusion, ±dp/dtmax further significantly declined (Plt;0.05) at 60 min of reperfusion. In carvedilol group, the changes of LVSP, ±dp/dtmax, CO and LVEDP were the same as those in the control group after 3 h of AMI. In contrast, LVSP, ±dp/dtmax, CO, LVEDP and pulmonary capillary wedge (PCWP) recovered signific