antioxidant activity of a series of fluorinatedpyrano-nucleoside analogues of n4-benzoyl cytosine andn6-benzoyl adenine抗氧化活性的一系列fluorinatedpyrano-nucleoside n4-benzoyl胞嘧啶andn6-benzoyl腺嘌呤类似物.pdfVIP

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antioxidant activity of a series of fluorinatedpyrano-nucleoside analogues of n4-benzoyl cytosine andn6-benzoyl adenine抗氧化活性的一系列fluorinatedpyrano-nucleoside n4-benzoyl胞嘧啶andn6-benzoyl腺嘌呤类似物.pdf

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antioxidant activity of a series of fluorinatedpyrano-nucleoside analogues of n4-benzoyl cytosine andn6-benzoyl adenine抗氧化活性的一系列fluorinatedpyrano-nucleoside n4-benzoyl胞嘧啶andn6-benzoyl腺嘌呤类似物

Int. J. Mol. Sci. 2007, 8, 695-704 International Journal of Molecular Sciences ISSN 1422-0067 © 2007 by MDPI /ijms Full Research Paper Antioxidant Activity of a Series of Fluorinated 4 Pyrano-nucleoside Analogues of N -benzoyl Cytosine and 6 N -benzoyl Adenine 1 2 2 1 Chrysoula Spanou , Stella Manta , Dimitri Komiotis , Albiona Dervishi and Demetrios Kouretas 1,* 1 Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece 2 Department of Biochemistry and Biotechnology, Laboratory of Organic Chemistry, University of Thessaly, Larissa, Greece * Author to whom correspondence should be addressed; Tel.: +30 2410 565277; Fax: +30 2410 565290; E-mail: dkouret@uth.gr Received: 17 April 2007; in revised form: 12 June 2007 / Accepted: 15 June 2007 / Published: 20 July 2007 Abstract: Fluorinated nucleoside analogues are known as antitumor, antiviral and chemotherapeutic agents, although the antioxidant activity of this kind of molecules is not yet investigated. In this study we have tested the antioxidant activity of a series of modified pyrano-nucleoside analogues using three in vitro assays. Firstly, the antioxidant capacity of the products was assessed using the DPPH assay and secondly, in order to examine the ab