antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and bimantagomir-17-5p废除therapy-resistant神经母细胞瘤的生长通过p21和荡妇.pdfVIP
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antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and bimantagomir-17-5p废除therapy-resistant神经母细胞瘤的生长通过p21和荡妇
Antagomir-17-5p Abolishes the Growth of Therapy-
Resistant Neuroblastoma through p21 and BIM
1 1. 2. 2 1 2
Laura Fontana *, Micol E. Fiori , Sonia Albini , Loredana Cifaldi , Serena Giovinazzi , Matteo Forloni ,
3 4 5 6 1,7
Renata Boldrini , Alberto Donfrancesco , Valentina Federici , Patrizio Giacomini , Cesare Peschle ,
Doriana Fruci2
` `
1 Department of Hematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome, Italy, 2 Research Center, Ospedale Pediatrico Bambino Gesu, Rome,
` `
Italy, 3 Division of Pathology, Ospedale Pediatrico Bambino Gesu, Rome, Italy, 4 Division of Pediatric Oncology, Ospedale Pediatrico Bambino Gesu, Rome, Italy,
5 Pathology Laboratory, Regina Elena Cancer Institute, Rome, Italy, 6 Laboratory of Immunology, Regina Elena Cancer Institute, Rome, Italy, 7 IRCCS MultiMedica, Milan,
Italy
Abstract
We identified a key oncogenic pathway underlying neuroblastoma progression: specifically, MYCN, expressed at elevated
level, transactivates the miRNA 17-5p-92 cluster, which inhibits p21 and BIM translation by interaction with their mRNA 39
UTRs. Overexpression of miRNA 17-5p-92 cluster in MYCN-not-amplified neuroblastoma cells strongly augments their in vitro
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