anopheles gambiae pgrplc-mediated defense against bacteria modulates infections with malaria parasites冈比亚疟蚊pgrplc-mediated防御细菌调节感染疟疾寄生虫.pdfVIP

Anopheles gambiae PGRPLC-Mediated Defense against Bacteria Modulates Infections with Malaria Parasites 1.¤a 2. 1. ´ 3¤b 4,5 Stephan Meister , Bogos Agianian , Fanny Turlure , Angela Relogio , Isabelle Morlais , Fotis C. 1 1 Kafatos , George K. Christophides * 1 Division of Cell and Molecular Biology, Department of Life Sciences, Imperial College London, London, United Kingdom, 2 Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandropolis, Greece, 3 European Molecular Biology Laboratory, Heidelberg, Germany, 4 Organisation de Coordination de la ´ ´ ´ lutte contre les Endemies en Afrique Centrale, Laboratoire de Recherche sur le Paludisme, Yaounde, Cameroon, 5 Institut de Recherche pour le Developpement - Laboratoire de Lutte contre les Insectes Nuisibles, UR 016, BP 64501, Montpellier, France Abstract Recognition of peptidoglycan (PGN) is paramount for insect antibacterial defenses. In the fruit fly Drosophila melanogaster, the transmembrane PGN Recognition Protein LC (PGRP-LC) is a receptor of the Imd signaling pathway that is activated after infection with bacteria, mainly Gram-negative (Gram2). Here we demonstrate that bacterial infections of the malaria mosquito Anopheles gambiae are sensed by the orthologous PGRPLC protein which then activates a signaling pathway that involves the Rel/NF-kB transcription factor REL2. PGRPLC signaling leads to transcriptiona