amyloid precursor protein is required for normal function of the rod and cone pathways in the mouse retina淀粉样前体蛋白的正常功能需要鼠标视网膜的视杆细胞和视锥通路.pdfVIP

Amyloid Precursor Protein Is Required for Normal Function of the Rod and Cone Pathways in the Mouse Retina 1,2,3 1 2,3 4,5,6 ´ ´ 4,5,6 Tracy Ho , Kirstan A. Vessey , Roberto Cappai , Virginie Dinet , Frederic Mascarelli , 2,3 1 Giuseppe D. Ciccotosto , Erica L. Fletcher * 1 Department of Anatomy Cell Biology, The University of Melbourne, Melbourne, Victoria, Australia, 2 Department of Pathology, The University of Melbourne, Melbourne, Victoria, Australia, 3 Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, Victoria, Australia, 4 Centre de Recherche ´ ´ ´ ´ des Cordeliers, Universite Paris Descartes, Paris, France, 5 Institut National de la Sante et de la Recherche Medicale, Paris, France, 6 Universite Pierre et Marie Curie, Paris, France Abstract Amyloid precursor protein (APP) is a transmembrane glycoprotein frequently studied for its role in Alzheimer’s disease. Our recent study in APP knockout (KO) mice identified an important role for APP in modulating normal neuronal development in the retina. However the role APP plays in the adult retina and whether it is required for vision is unknown. In this study we evaluated the role of APP in retinal function and morphology comparing adult wildtype (WT) and APP-KO mice. APP was expressed on neuronal cells of the inner retina, including horizontal, cone bipolar, amacrine and ganglion cells in WT mice. The function of the retina was assessed using the electroretinogram and although the rod photoreceptor responses w