有哪些信誉好的足球投注网站an investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north indians全基因组研究的调查报告对溃疡性结肠炎易感性位点显示有限的复制在北印度人.pdfVIP
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an investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north indians全基因组研究的调查报告对溃疡性结肠炎易感性位点显示有限的复制在北印度人
An Investigation of Genome-Wide Studies Reported
Susceptibility Loci for Ulcerative Colitis Shows Limited
Replication in North Indians
1 1 1 2 2
Garima Juyal , Pushplata Prasad , Sabyasachi Senapati , Vandana Midha , Ajit Sood , Devendra
3,4 5 1
Amre , Ramesh C. Juyal , Thelma BK *
1 Department of Genetics, University of Delhi, South Campus, New Delhi, India, 2 Dayanand Medical College and Hospital, Ludhiana, Punjab, India, 3 Department of
Pediatrics, University of Montreal, Montreal, Canada, 4 Research Center, Sainte-Justine Hospital, Montreal, Canada, 5 National Institute of Immunology, New Delhi, India
Abstract
Genome-Wide Association studies (GWAS) of both Crohn’s Disease (CD) and Ulcerative Colitis (UC) have unearthed over 40
risk conferring variants. Recently, a meta-analysis on UC revealed several loci, most of which were either previously
associated with UC or CD susceptibility in populations of European origin. In this study, we attempted to replicate these
findings in an ethnically distinct north Indian UC cohort. 648 UC cases and 850 controls were genotyped using Infinium
Human 660W-quad. Out of 59 meta-analysis index SNPs, six were not in the SNP array used in the study. Of the remaining 53
SNPs, four were found monomorphic. Association (p,0.05) at 25 SNPs was observed, of which 15 were CD specific. Only five
SNPs namely rs2395185 (HLA-DRA), rs3024505 (IL10), rs6426833 (RNF186), rs3763313 (BTNL2) and rs2066843 (NOD2) retained
significance after Bonferroni correction. These results (i) reveal limited replication of Caucasian based meta-analysis results;
(ii) reiterate overlapping molecular mechanism(s) in UC and CD; (iii) indicate differences in genetic architectur
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