amyloid precursor protein is trafficked and secreted via synaptic vesicles淀粉样前体蛋白是贩卖并通过突触囊泡分泌.pdfVIP

Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles 1,6. 1,2. 3 . 4 1,2 ¨ 5 Teja W. Groemer , Cora S. Thiel , Matthew Holt * , Dietmar Riedel , Yunfeng Hua , Jana Huve , 1 ¨ 1,2 Benjamin G. Wilhelm , Jurgen Klingauf * ¨ 1 Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany, 2 Institute of Medical Physics and Biophysics, University of ¨ ¨ ¨ Munster, Munster, Germany, 3 Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, Gottingen, Germany, 4 Electron Microscopy Group, Max ¨ ¨ Planck Institute for Biophysical Chemistry, Gottingen, Germany, 5 Fluorescence Microscopy Facility Munster, Institute of Medical Physics and Biophysics, University of ¨ ¨ Munster, Munster, Germany, 6 Department of Psychiatry and Psychotherapy, University of Erlangen, Erlangen, Germany Abstract A large body of evidence has implicated amyloid precursor protein (APP) and its proteolytic derivatives as key players in the physiological context of neuronal synaptogenesis and synapse maintenance, as well as in the pathology of Alzheimer’s Disease (AD). Although APP processing and release are known to occur in response to neuronal stimulation, the exact mechanism by which AP