an accurate definition of the status of inactive hepatitis b virus carrier by a combination of biomarkers (fibrotest-actitest) and viral load不活跃的状态的准确定义乙型肝炎病毒载体的结合生物标志物(fibrotest-actitest)和病毒载量.pdfVIP
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an accurate definition of the status of inactive hepatitis b virus carrier by a combination of biomarkers (fibrotest-actitest) and viral load不活跃的状态的准确定义乙型肝炎病毒载体的结合生物标志物(fibrotest-actitest)和病毒载量
An Accurate Definition of the Status of Inactive Hepatitis
B Virus Carrier by a Combination of Biomarkers
(FibroTest-ActiTest) and Viral Load
1 1 2 1 3 1
Yen Ngo , Yves Benhamou , Vincent Thibault , Patrick Ingiliz , Mona Munteanu , Pascal Lebray ,
1 1 4 5 4
Dominique Thabut , Rachel Morra , Djamila Messous , Frederic Charlotte , Franc¸oise Imbert-Bismut ,
4 1 1 1
Dominique Rousselot-Bonnefont , Joseph Moussalli , Vlad Ratziu , Thierry Poynard *
´ ´ ´ ˆ ` ´
1 Service d’Hepato-Gastroenterologie, Groupe Hospitalier Pitie-Salpetriere, Universite Paris VI, CNRS UMR 8149, Paris, France, 2 Laboratoire de Virologie, Groupe
´ ˆ ` ´ ´ ´ ˆ `
Hospitalier Pitie-Salpetriere, Paris, France, 3 Biopredictive, Paris, France, 4 Federation de Biochimie, Groupe Hospitalier Pitie-Salpetriere, Paris, France, 5 Service d’Anatomie
´ ˆ `
Pathologique Groupe Hospitalier Pitie-Salpetriere, Paris, France
Abstract
Background: The combination of transaminases (ALT), biopsy, HBeAg and viral load have classically defined the inactive
status of carriers of chronic hepatitis B. The use of FibroTest (FT) and ActiTest (AT), biomarkers of fibrosis and
necroinflammatory activity, has been previously validated as alternative
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