有哪些信誉好的足球投注网站aging contributes to inflammation in upper extremity tendons and declines in forelimb agility in a rat model of upper extremity overuse老化导致炎症在上肢肌腱和下降前肢敏捷性上肢过度使用的大鼠模型.pdfVIP
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aging contributes to inflammation in upper extremity tendons and declines in forelimb agility in a rat model of upper extremity overuse老化导致炎症在上肢肌腱和下降前肢敏捷性上肢过度使用的大鼠模型
Aging Contributes to Inflammation in Upper Extremity
Tendons and Declines in Forelimb Agility in a Rat Model
of Upper Extremity Overuse
1 2 3 4 3
David M. Kietrys , Ann E. Barr-Gillespie , Mamta Amin , Christine K. Wade , Steve N. Popoff ,
Mary F. Barbe3*
1 Department of Rehabilitation and Movement Sciences, University of Medicine and Dentistry of New Jersey, School of Health Related Professions, Stratford, New Jersey,
United States of America, 2 College of Health Professions, Pacific University, Hillsboro, Oregon, United States of America, 3 Department of Anatomy and Cell Biology,
Temple University School of Medicine, Philadelphia, Pennsylvania, United States of America, 4 Department of Physical Therapy, Thomas Jefferson University, Philadelphia,
Pennsylvania, United States of America
Abstract
We sought to determine if tendon inflammatory and histopathological responses increase in aged rats compared to young
rats performing a voluntary upper extremity repetitive task, and if these changes are associated with motor declines. Ninety-
six female Sprague-Dawley rats were used in the rat model of upper extremity overuse: 67 aged and 29 young adult rats.
After a training period of 4 weeks, task rats performed a voluntary high repetition low force (HRLF) handle-pulling task for
2 hrs/day, 3 days/wk for up to 12 weeks. Upper extremity motor function was assessed, as were inflammatory and
histomorphological changes in flexor digitorum and supraspinatus tendons. The percentage of successful reaches improved
in young adult HRLF rats, but not in aged HRLF rats. Forelimb agility decreased transiently in young adult HRLF rats, but
persistently in aged HRLF rats. HRLF task performance for 12 weeks lead to increased IL-1beta and IL-6 in flexor digitorum
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