有哪些信誉好的足球投注网站activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody激活血小板在颈动脉血栓形成与放射性标记的小鼠可以有选择地针对单链抗体.pdfVIP
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activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody激活血小板在颈动脉血栓形成与放射性标记的小鼠可以有选择地针对单链抗体
Activated Platelets in Carotid Artery Thrombosis in Mice
Can Be Selectively Targeted with a Radiolabeled
Single-Chain Antibody
1 . 2. 3. ¨ 4 5
Timo Heidt * , Friederike Deininger , Karlheinz Peter , Jurgen Goldschmidt , Annette Pethe ,
3 1 1 2 1
Christoph E. Hagemeyer , Irene Neudorfer , Andreas Zirlik , Wolfgang A. Weber , Christoph Bode ,
2 2. ¨ 1.
Philipp T. Meyer , Martin Behe , Constantin von zur Muhlen
1 Department of Cardiology and Angiology, University of Freiburg, Freiburg, Germany, 2 Department of Nuclear Medicine, University of Freiburg, Freiburg, Germany,
3 Baker IDI Heart and Diabetes Institute, Melbourne, Australia, 4 Leibniz-Institute for Neurobiology, Magdeburg, Germany, 5 Department of Nuclear Medicine, University of
Magdeburg, Magdeburg, Germany
Abstract
Background: Activated platelets can be found on the surface of inflamed, rupture-prone and ruptured plaques as well as in
intravascular thrombosis. They are key players in thrombosis and atherosclerosis. In this study we describe the construction
of a radiolabeled single-chain antibody targeting the LIBS-epitope of activated platelets to selectively depict platelet
activation and wall-adherent non-occlusive thrombosis in a mouse model with nuclear imaging using in vitro and ex vivo
autoradiography as well as small animal SPECT-CT for in vivo analysis.
Methodology/Principal Findings: LIBS as well as an unspecific control single-chain antibody were labeled with 111Indium
(111In) via bifu
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