有哪些信誉好的足球投注网站aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation衰老造血干细胞功能下降和表观遗传失调.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation衰老造血干细胞功能下降和表观遗传失调
PLoS BIOLOGY
Aging Hematopoietic Stem Cells Decline
in Function and Exhibit Epigenetic
Dysregulation
1,2 2,3 1,4 3 1,4,5
Stuart M. Chambers , Chad A. Shaw , Catherine Gatza , C. Joseph Fisk , Lawrence A. Donehower ,
Margaret A. Goodell1,2,3,6*
1 Program for Cell and Molecular Biology, Baylor College of Medicine, Houston, Texas, United States of America, 2 Stem Cells and Regenerative Medicine Center, Baylor
College of Medicine, Houston, Texas, United States of America, 3 Department of Molecular Human Genetics, Baylor College of Medicine, Houston, Texas, United States of
America, 4 Department of Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, 5 Department of Molecular and Cellular Biology,
Baylor College of Medicine, Houston, Texas, United States of America, 6 Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America
Age-related defects in stem cells can limit proper tissue maintenance and hence contribute to a shortened lifespan.
Using highly purified hematopoietic stem cells from mice aged 2 to 21 mo, we demonstrate a deficit in function yet an
increase in stem cell number with advancing age. Expression analysis of more than 14,000 genes identified 1,500 that
were age-induced and 1,600 that were age-repressed. Genes associated with the stress response, inflammation, and
protein aggregation dominated the up-regulated expression profile, while the down-regulated profile was marked by
genes involved in the preservation of genomic integrity and chromatin remodeling. Many chromosomal regions
showed coordinate loss of transcriptional regulation; an overall increase in transcriptional activity with age and
inappropriate expression of genes normally regulated by epigenetic mechanisms w
您可能关注的文档
- activation of ampa receptors in the suprachiasmatic nucleus phase-shifts the mouse circadian clock in vivo and in vitroampa受体的激活视交叉上核相移鼠标生物钟体内和体外.pdf
- activation mobilizes the cholesterol in the late endosomes-lysosomes of niemann pick type c cells活化动员尼曼皮克类型的胆固醇endosomes-lysosomes末c细胞.pdf
- activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody激活血小板在颈动脉血栓形成与放射性标记的小鼠可以有选择地针对单链抗体.pdf
- activation of arabidopsis seed hair development by cotton fiber-related genes激活的拟南芥种子发发展棉花纤维相关的基因.pdf
- activated met signalling in the developing mouse heart leads to cardiac disease激活了信号在发展中老鼠心脏导致心脏疾病.pdf
- activation and proteolytic activity of the treponema pallidum metalloprotease, pallilysin激活和蛋白水解活性的梅毒螺旋体metalloprotease,pallilysin.pdf
- activation of cell cycle arrest and apoptosis by the proto-oncogene pim-2原癌基因激活的细胞周期阻滞和细胞凋亡的pim-2.pdf
- activation of c-jun n-terminal kinase (jnk) during mitosis in retinal progenitor cells激活c-jun n端激酶(物)在视网膜祖细胞有丝分裂.pdf
- activation of an nlrp3 inflammasome restricts mycobacterium kansasii infection激活一个nlrp3 inflammasome限制kansasii分枝杆菌感染.pdf
- activation of cd40 with platelet derived cd154 promotes reactive oxygen species dependent death of human hepatocytes during hypoxia and reoxygenation与血小板激活cd40派生cd154促进活性氧相关死亡的人类肝细胞在缺氧和再氧化.pdf
- aging in a long-lived clonal tree长寿克隆树老化.pdf
- aging worsens the effects of sleep deprivation on postural control老龄化加剧剥夺睡眠姿势控制的影响.pdf
- aging kit mutant mice develop cardiomyopathy老化设备突变小鼠发展心肌病.pdf
- aging and death in an organism that reproduces by morphologically symmetric division衰老和死亡的生物形态对称分裂繁殖的.pdf
- aging, aerobic activity and interhemispheric communication衰老,有氧运动和两半球间的通信.pdf
- aging effect on neurotrophic activity of human mesenchymal stem cells老化效应在人类间充质干细胞的神经营养活性.pdf
- ago-2-mediated slicer activity is essential for anti-flaviviral efficacy of rnaiago-2-mediated切片机活动对于anti-flaviviral rnai的功效是至关重要的.pdf
- aging of xenopus tropicalis eggs leads to deadenylation of a specific set of maternal mrnas and loss of developmental potential老化的非洲爪蟾蜍tropicalis鸡蛋会导致deadenylation一组特定的孕产妇mrna和发展潜在的损失.pdf
- ago hits-clip expands understanding of kaposi's sarcoma-associated herpesvirus mirna function in primary effusion lymphomas前hits-clip扩大理解卡波济氏肉瘤相关疱疹病毒microrna的函数在初级积液淋巴瘤.pdf
- ago1 and ago2 act redundantly in mir408-mediated plantacyanin regulationago1和ago2冗mir408-mediated plantacyanin监管.pdf
文档评论（0）