administration of urb597, oleoylethanolamide or palmitoylethanolamide increases waking and dopamine in ratsurb597 oleoylethanolamide总局或者增加palmitoylethanolamide清醒和多巴胺的老鼠.pdfVIP

Administration of URB597, Oleoylethanolamide or Palmitoylethanolamide Increases Waking and Dopamine in Rats ´ 1 2 ´ 2 ´ 3 ´ Eric Murillo-Rodrıguez *, Marcela Palomero-Rivero , Diana Millan-Aldaco , Oscar Arias-Carrion , Rene ´ 2 Drucker-Colın ´ ´ ´ ´ ´ 1 Laboratorio de Neurociencias Moleculares e Integrativas, Escuela de Medicina, Division Ciencias de la Salud, Universidad Anahuac Mayab, Merida, Yucatan, Mexico, ´ ´ ´ ´ ´ ´ 2 Division de Neurociencias, Instituto de Fisiologıa Celular, Universidad Nacional Autonoma de Mexico, Mexico DF, Mexico, 3 Department of Neurology, Philipps- ¨ Universitat, Marburg, Germany Abstract Background: Oleoylethanolamide (OEA) and palmitoylethanolamide (PEA) are amides of fatty acids and ethanolamine named N-acylethanolamines or acylethanolamides. The hydrolysis of OEA and PEA is catalyzed by the fatty acid amide hydrolase (FAAH). A number of FAAH inhibitors that increase the levels of OEA and PEA in the brain have been developed, including URB597. In the present report, we examined whether URB597, OEA or PEA injected into wake-related brain areas, such as lateral hypothalamus (LH) or dorsal raphe nuclei (DRN) would promote wakefulness (W) in rats. Methodology and Principal Findings: Male Wistar rats (250–300 g) were implanted for sleep studies with electrodes to record the electroencephalogra