adolescent binge drinking leads to changes in alcohol drinking, anxiety, and amygdalar corticotropin releasing factor cells in adulthood in male rats青少年酗酒导致饮酒的变化,焦虑,amygdalar促肾上腺皮质激素释放因子细胞在成年雄性老鼠.pdfVIP

Adolescent Binge Drinking Leads to Changes in Alcohol Drinking, Anxiety, and Amygdalar Corticotropin Releasing Factor Cells in Adulthood in Male Rats 1 2 2 Nicholas W. Gilpin , Chrisanthi A. Karanikas , Heather N. Richardson * 1 Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America, 2 Department of Psychology (Neuroscience and Developmental Divisions), Neuroscience and Behavior Program, Center for Neuroendocrine Studies, The University of Massachusetts-Amherst, Amherst, Massachusetts, United States of America Abstract Heavy episodic drinking early in adolescence is associated with increased risk of addiction and other stress-related disorders later in life. This suggests that adolescent alcohol abuse is an early marker of innate vulnerability and/or binge exposure impacts the developing brain to increase vulnerability to these disorders in adulthood. Animal models are ideal for clarifying the relationship between adolescent and adult alcohol abuse, but we show that methods of involuntary alcohol exposure are not effective. We describe an operant model that uses multiple bouts of intermittent access to sweetened alcohol to elicit voluntary binge alcohol drinking early in adolescence (,postnatal days 28–42) in genetically heterogeneous male Wistar rats. We next examined the effects of adolescent binge drinking on alcohol drinking and anxiety-like behavior in dependent and non-dependent adult rats, and counted corticotropin-releasing factor (CRF) cell in the lateral portion of the central amygdala (CeA), a region that contributes to regulation of anxiety- and alcohol-related behaviors. Adolescent binge drinking did not alter alcohol drinking under baseline drinking conditions in adul