abnormal distracter processing in adults with attention-deficit-hyperactivity disorder异常干扰项处理成人注意缺陷多动障碍.pdfVIP

Abnormal Distracter Processing in Adults with Attention- Deficit-Hyperactivity Disorder 1,2 1 ¨ 1 2 2 Frank Marzinzik , Michael Wahl , Doris Kruger , Laura Gentschow , Michael Colla , Fabian Klostermann1* ´ ´ 1 Department of Neurology, Campus Benjamin Franklin, Charite–University Medicine, Berlin, Germany, 2 Department of Psychiatry, Campus Benjamin Franklin, Charite– University Medicine, Berlin, Germany Abstract Background: Subjects with Attention-Deficit Hyperactivity Disorder (ADHD) are overdistractible by stimuli out of the intended focus of attention. This control deficit could be due to primarily reduced attentional capacities or, e. g., to overshooting orienting to unexpected events. Here, we aimed at identifying disease-related abnormalities of novelty processing and, therefore, studied event-related potentials (ERP) to respective stimuli in adult ADHD patients compared to healthy subjects. Methods: Fifteen unmedicated subjects with ADHD and fifteen matched controls engaged in a visual oddball task (OT) under simultaneous EEG recordings. A target stimulus, upon which a motor response was required, and non-target stimuli, which did not demand a specific reaction, were presented in random order. Target and most non-target stimuli were presented repeatedly, but some non-target stimuli occurred only once (‘novels’). These unique stimuli were either ‘relative novels’ with which a meaning could be associated, or ‘complete novels’, if no association was available. Results: In frontal recordings, a