absence of association between n-acetyltransferase 2 acetylator status and colorectal cancer susceptibility based on evidence from 40 studies之间缺乏联系n-acetyltransferase 2乙酰化器状态和基于证据从40研究大肠癌易感性.pdfVIP

下载本文档

4
0
约4.78万字
约 7页
2017-09-07 发布于上海
举报
版权申诉

absence of association between n-acetyltransferase 2 acetylator status and colorectal cancer susceptibility based on evidence from 40 studies之间缺乏联系n-acetyltransferase 2乙酰化器状态和基于证据从40研究大肠癌易感性.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

absence of association between n-acetyltransferase 2 acetylator status and colorectal cancer susceptibility based on evidence from 40 studies之间缺乏联系n-acetyltransferase 2乙酰化器状态和基于证据从40研究大肠癌易感性

Absence of Association between N-Acetyltransferase 2 Acetylator Status and Colorectal Cancer Susceptibility: Based on Evidence from 40 Studies 1,2 . 1. 2 3 4 3 Lou qian Zhang * , Jian nong Zhou , Jun Wang *, Guo dong Liang , Jing ying Li , Yi dan Zhu , Yun tao Su4 1 Colorectal and Anal Surgery Center, The Affiliated Jiangsu Cancer Hospital of Nanjing Medical University, Nanjing, China, 2 Department of Chemotherapy, Jiangsu Geriatric Institute, Jiangsu Official Hospital, Nanjing, China, 3 Department of Gastroenterology, Jiangsu Geriatric Institute, Jiangsu Official Hospital, Nanjing, China, 4 Department of Medical Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Abstract Background and Objectives: N-Acetyltransferase (NAT) 2 is an important enzyme involved in the metabolism of different xenobiotics, including potential carcinogens, whose phenotypes were reported to be related to individual susceptibility to colorectal cancer (CRC). However, the results remain conflicting. To assess the relationship between NAT2 phenotypes and CRC risk, we performed this meta-analysis. Methods: A comprehensive literature search was conducted to identify all case-control or cohort studies of NAT2 acetylator status on the susceptibility of CRC by searching of PubMed and EMBASE, up to May 20, 2011. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the association. Results: A total of over 40,000 subjects from 40 published literatures were identified by searching the databases. No significantly elevated CRC risk in individuals with NAT2 slow acetylators compared with fast acetylators was found when all studies pooled (OR = 0.95, 95%