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active protein aggregates produced in escherichia coli大肠杆菌生产的活性蛋白质聚合
Int. J. Mol. Sci. 2011, 12, 8275-8287; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Review
Active Protein Aggregates Produced in Escherichia coli
Špela Peternel 1,2,* and Radovan Komel 1,2
1
Laboratory for Biosynthesis and Biotransformation, National Institute of Chemistry, Hajdrihova 19,
1000 Ljubljana, Slovenia; E-Mail: radovan.komel@mf.uni-lj.si
2
Medical Centre for Molecular Biology, Medical faculty, University of Ljubljana, Vrazov trg 2,
1000 Ljubljana, Slovenia
* Author to whom correspondence should be addressed; E-Mail: spela.peternel@ki.si;
Tel.: +386-1-4760-262; Fax: +386-1-4760-300.
Received: 12 October 2011; in revised form: 11 November 2011 / Accepted: 11 November 2011 /
Published: 22 November 2011
Abstract: Since recombinant proteins are widely used in industry and in research, the need
for their low-cost production is increasing. Escherichia coli is one of the best known and
most often used host organisms for economical protein production. However, upon over-
expression, protein aggregates called inclusion bodies (IBs) are often formed. Until
recently IBs formation represented a bottleneck in protein production as they were
considered as deposits of inactive proteins. However, recent studies show that by choosing
the appropriate host strain and designing an optimal production process, IBs
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