activated k-ras and ink4aarf deficiency cooperate during the development of pancreatic cancer by activation of notch and nf-κb signaling pathwaysk - ras基因激活和ink4aarf缺乏合作的开发过程中胰腺癌切口和nf-κb信号通路的激活.pdfVIP

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activated k-ras and ink4aarf deficiency cooperate during the development of pancreatic cancer by activation of notch and nf-κb signaling pathwaysk - ras基因激活和ink4aarf缺乏合作的开发过程中胰腺癌切口和nf-κb信号通路的激活.pdf

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activated k-ras and ink4aarf deficiency cooperate during the development of pancreatic cancer by activation of notch and nf-κb signaling pathwaysk - ras基因激活和ink4aarf缺乏合作的开发过程中胰腺癌切口和nf-κb信号通路的激活

Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-kB Signaling Pathways 1. 1. 1 1 1 5,6 Zhiwei Wang , Sanjeev Banerjee , Aamir Ahmad , Yiwei Li , Asfar S. Azmi , Jason R. Gunn , Dejuan 1 1 2 2,3 2 4 5,6 Kong , Bin Bao , Shadan Ali , Jiankun Gao , Ramzi M. Mohammad , Lucio Miele , Murray Korc , Fazlul H. Sarkar1* 1 Department of Pathology, Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan, United States of America, 2 Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, Wayne State University, Detroit, Michigan, United States of America, 3 Sichuan College of Tranditional Chinese Medicine, Mianyang, Sichuan, People’s Republic of China, 4 University of Mississippi Cancer Institute, Jackson, Mississippi, United States of America, 5 Department of Medicine and Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire, United States of America, 6 Norris Cotton Comprehsive Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States of America Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death in the United States, suggesting that novel strategies for the prevention and treatment of PDAC are urgently needed. K-ras mutations are observed in .90% of pancreatic cancer, suggesting its role in the initiation and early developmental stages of PDAC. In order to gain mechanisti