a tumor surveillance model a non-coding rna senses neoplastic cells and its protein partner signals cell death肿瘤监测模型非编码rna的感官肿瘤细胞及其细胞死亡蛋白伴侣信号.pdfVIP

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a tumor surveillance model a non-coding rna senses neoplastic cells and its protein partner signals cell death肿瘤监测模型非编码rna的感官肿瘤细胞及其细胞死亡蛋白伴侣信号.pdf

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a tumor surveillance model a non-coding rna senses neoplastic cells and its protein partner signals cell death肿瘤监测模型非编码rna的感官肿瘤细胞及其细胞死亡蛋白伴侣信号

Int. J. Mol. Sci. 2012, 13, 13134-13139; doi:10.3390/ijms131013134 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Communication A Tumor Surveillance Model: A Non-Coding RNA Senses Neoplastic Cells and Its Protein Partner Signals Cell Death Sung Ho Jeon 1, Betty H. Johnson 2 and Yong Sun Lee 2,* 1 Department of Life Science, Hallym University, Chuncheon 200-702, Korea; E-Mail: sjeon@hallym.ac.kr 2 Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX77555, USA; E-Mail: bhjohnso@ * Author to whom correspondence should be addressed; E-Mail: yslee@; Tel.: +1-409-772-2373; Fax: +1-409-772-8028. Received: 31 July 2012; in revised form: 22 September 2012 / Accepted: 26 September 2012 / Published: 12 October 2012 Abstract: nc886 (= pre-miR-886 or vtRNA2-1) is a non-coding RNA that has been recently identified as a natural repressor for the activity of PKR (Protein Kinase R). The suppression of nc886 activates PKR and thereby provokes a cell death pathway. When combined with the fact that nc886 is suppressed in a wide range of cancer cells, the nc886-PKR relationship suggests a tumor surveillance model. When neoplastic cells develop and nc886 decreases therein, PKR is released from nc886 and becomes the active phosphorylated form, which initiates an apoptotic cas