有哪些信誉好的足球投注网站actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein m6aactin-independent行为和m6a four-transmembrane膜变形表现出的蛋白质.pdfVIP
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actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein m6aactin-independent行为和m6a four-transmembrane膜变形表现出的蛋白质
Actin-Independent Behavior and Membrane
Deformation Exhibited by the Four-Transmembrane
Protein M6a
1¤ 2 3 1 1
Yasufumi Sato , Naoki Watanabe , Nanae Fukushima , Sakura Mita , Tatsumi Hirata *
1 Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies (Sokendai), Mishima, Shizuoka, Japan, 2 Laboratory of Single-
Molecule Cell Biology, Tohoku University Graduate School of Life Sciences, Sendai, Miyagi, Japan, 3 Department of Anatomy, Shinshu University School of Medicine,
Matsumoto, Nagano, Japan
Abstract
M6a is a four-transmembrane protein that is abundantly expressed in the nervous system. Previous studies have shown that
over-expression of this protein induces various cellular protrusions, such as neurites, filopodia, and dendritic spines. In this
detailed characterization of M6a-induced structures, we found their varied and peculiar characteristics. Notably, the M6a-
induced protrusions were mostly devoid of actin filaments or microtubules and exhibited free random vibrating motion.
Moreover, when an antibody bound to M6a, the membrane-wrapped protrusions were suddenly disrupted, leading to
perturbation of the surrounding membrane dynamics involving phosphoinositide signaling. During single-molecule
analysis, M6a exhibited cytoskeleton-independent movement and became selectively entrapped along the cell perimeter in
an actin-independent manner. These observations highlight the unusual characteristics of M6a, which may have a
significant yet unappreciated role in biological systems.
Citation: Sato Y, Watanabe N, Fukushima N, Mita S, Hirata T (2011) Actin-Independent Behavior an
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