有哪些信誉好的足球投注网站a translational regulator, pum2, promotes both protein stability and kinase activity of aurora-apum2平移监管机构,促进蛋白质的稳定性和aurora-a激酶活性.pdfVIP
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a translational regulator, pum2, promotes both protein stability and kinase activity of aurora-apum2平移监管机构,促进蛋白质的稳定性和aurora-a激酶活性
A Translational Regulator, PUM2, Promotes Both Protein
Stability and Kinase Activity of Aurora-A
1 2 3 1
Yei-Hsuan Huang , Chun-Chi Wu , Chen-Kung Chou *, Chi-Ying F. Huang *
1 Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, 2 Institute of Medicine, Chung-Shan Medical University, Taichung, Taiwan, 3 Department of
Life Science, Chang-Gung University, Tao-Yuan, Taiwan
Abstract
Aurora-A, a centrosomal serine-threonine kinase, orchestrates several key aspects of cell division. However, the regulatory
pathways for the protein stability and kinase activity of Aurora-A are still not completely understood. In this study, PUM2, an
RNA-binding protein, is identified as a novel substrate and interacting protein of Aurora-A. Overexpression of the PUM2
mutant which fails to interact with Aurora-A, and depletion of PUM2 result in a decrease in the amount of Aurora-A. PUM2
physically binds to the D-box of Aurora-A, which is recognized by APC/CCdh1. Overexpression of PUM2 prevents
ubiquitination and enhances the protein stability of Aurora-A, suggesting that PUM2 protects Aurora-A from APC/CCdh1-
mediated degradation. Moreover, association of PUM2 with Aurora-A not only makes Aurora-A more stable but also
enhances the kinase activity of Aurora-A. Our study suggests that PUM2 plays two different but important roles during cell
cycle progression. In interphase, PUM2 localizes in cytoplasm and plays as translational repressor through its RNA binding
domain. However, in mitosis, PUM2 physically associates with Aurora-A to ensure enough active Aurora-A at centrosomes
for mitotic entry. This is the first time to reveal the moonlight role of PUM2 in mitosis.
Citation: Huang Y-H, Wu C-C, Chou C-K, Huang C-YF (201
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