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a statistical analysis of the robustness of alternate genetic coding tables替代基因编码的鲁棒性统计分析表
Int. J. Mol. Sci. 2008, 9, 679-697
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/ijms
Full Research Paper
A Statistical Analysis of the Robustness of Alternate Genetic
Coding Tables
Mehmet Levent Kurnaz 1, Tugce Bilgin 2 and Isil Aksan Kurnaz 2,*
1 Physics Department, Bogazici University Bebek, 34342 Istanbul, Turkey. E-mail:
levent.kurnaz@.tr
2 Department of Genetics and Bioengineering, Yeditepe University Kayisdagi, 34755 Istanbul,
Turkey. E-mail: tugce_bilgin@yahoo.co.uk. E-mail: iakurnaz@.tr
* Author to whom correspondence should be addressed.
Received: 18 December 2007; in revised form: 25 February 2008 / Accepted: 11 April 2008 /
Published: 2 May 2008
Abstract: The rules that specify how the information contained in DNA is translated into
amino acid “language” during protein synthesis are called “the genetic code”, commonly
called the “Standard” or “Universal” Genetic Code Table. As a matter of fact, this coding
table is not at all “universal”: in addition to different genetic code tables used by different
organisms, even within the same organism the nuclear and mitochondrial genes may be
subject to two different coding tables. Results In an attempt to understand the advantages
and disadvantages these coding tables may bring to an organism, we have decided to
analyze various coding tables on genes subject to mutations, and have estimated how these
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