abnormalities of white matter microstructure in unmedicated obsessive-compulsive disorder and changes after medication异常的白质微结构犯人强迫症和药物治疗后的变化.pdfVIP

Abnormalities of White Matter Microstructure in Unmedicated Obsessive-Compulsive Disorder and Changes after Medication 1. 2. 1. 3 1 1 4 4 Qing Fan , Xu Yan , Jijun Wang , Ying Chen , Xuemei Wang , Chunbo Li , Ling Tan , Chao You , 1 1 2 3 5 1 Tianhong Zhang , Sai Zuo , Dongrong Xu *, Kemin Chen , Jodie Marie Finlayson-Burden , Zeping Xiao * 1 Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2 Key Laboratory of Brain Functional Genomics, Ministry of Education, Shanghai Key Laboratory of Brain Functional Genomics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China, 3 Shanghai TCM-Intergrated Hospital, Shanghai, China, 4 Radiology Department, School of Medicine, Shanghai Jiao Tong University, Ruijin Hospital, Shanghai, China, 5 Nottingham Institute of Mental Health, University of Nottingham, Nottingham, England Abstract Background: Abnormalities of myelin integrity have been reported in obsessive-compulsive disorder (OCD) using multi- parameter maps of diffusion tensor imaging (DTI). However, it was still unknown to what degree these abnormalities might be affected by pharmacological treatment. Objective: To investigate whether the abnormalities of white matter microstructure including myelin integrity exist in OCD and whether they are affected by medication. Methodology and Principal Findings: Parameter maps of DTI, including fractional anisotropy (FA), axial diffusivity (AD),