a soluble receptor for advanced glycation end-products inhibits hypoxiareoxygenation-induced apoptosis in rat cardiomyocytes via the mitochondrial pathway晚期糖化终产物的可溶性受体抑制hypoxiareoxygenation-induced通过线粒体途径在大鼠心肌细胞凋亡.pdfVIP

a soluble receptor for advanced glycation end-products inhibits hypoxiareoxygenation-induced apoptosis in rat cardiomyocytes via the mitochondrial pathway晚期糖化终产物的可溶性受体抑制hypoxiareoxygenation-induced通过线粒体途径在大鼠心肌细胞凋亡.pdf

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a soluble receptor for advanced glycation end-products inhibits hypoxiareoxygenation-induced apoptosis in rat cardiomyocytes via the mitochondrial pathway晚期糖化终产物的可溶性受体抑制hypoxiareoxygenation-induced通过线粒体途径在大鼠心肌细胞凋亡

Int. J. Mol. Sci. 2012, 13, 11923-11940; doi:10.3390/ijms130911923 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article A Soluble Receptor for Advanced Glycation End-Products Inhibits Hypoxia/Reoxygenation-Induced Apoptosis in Rat Cardiomyocytes via the Mitochondrial Pathway Caixia Guo 1,†,*, Xiangjun Zeng 2,†, Juanjuan Song 1, Min Zhang 1, Hongxia Wang 2, 1 1 1 Xiaowei Xu , Fenghe Du and Buxing Chen 1 Department of Cardiology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China; E-Mails: songjuan2008@163.com (J.S.); dayanjingzm@ (M.Z.); xuxiaoweittyy@ (X.X.); fhduu@ (F.D.); chbux@126.com (B.C.) 2 Department of Pathophysiology, Capital Medical University, Beijing 100069, China; E-Mails: megan_zeng@163.com (X.Z.); whxdy@ (H.W.) † These authors contributed equally to this work. * Author to whom correspondence should be addressed. E-Mail: cxgbb@163.com; Tel.: +86-10-6709-6562; Fax: +86-10-6709-6567. Received: 28 June 2012; in revised form: 5 September 2012 / Accepted: 11 September 2012 / Published: 20 September 2012 Abstract: Severe myocardial dysfunction and tissue damage resulting from ischemia/reperfusion (I/R) is a common clinical scenario in patients with certain types of heart diseases and therapies such as thrombolysis, percutaneous coronary intervention, coronary artery bypass grafting, and card

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