有哪些信誉好的足球投注网站a soluble form of ctla-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with cd1d+ expression一种可溶性ctla-4存在于儿科急性淋巴细胞白血病患者和与cd1d +表达式.pdfVIP
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asolubleformofctla-4ispresentinpaediatricpatientswithacutelymphoblasticleukaemiaandcorrelateswithcd1dexpression一种可溶性ctla-4存在于儿科急性淋巴细胞白血病患者和与cd1d表达式
A Soluble Form of CTLA-4 Is Present in Paediatric
Patients with Acute Lymphoblastic Leukaemia and
Correlates with CD1d+ Expression
1,2 1 1 3 3 4
Rita Simone , Claudya Tenca , Franco Fais , Matteo Luciani , Giulio De Rossi , Giampaola Pesce ,
4 1
Marcello Bagnasco , Daniele Saverino *
1 Department of Experimental Medicine – Section of Human Anatomy, University of Genova, Genova, Italy, 2 The Feinstein Institute for Medical Research, North Shore-LIJ
`
Health System, Manhasset, New York, United States of America, 3 Department of Pediatric Haematology and Oncology, Ospedale Bambino Gesu, Rome, Italy, 4 Medical
and Radiometabolic Therapy Unit, Department of Internal Medicine, University of Genova, Genova, Italy
Abstract
CTLA-4 is a key factor in regulating and maintaining self tolerance, providing a negative signal to the T cell and thus limiting
immune responses. Several polymorphisms within the CTLA-4 gene have been associated with an increased risk of
developing autoimmune diseases and, very recently, with susceptibility to human cancer. Acute lymphoblastic leukemia is a
clonal disorder of lymphoid progenitors representing the most frequent malignancy of childhood. Here, we show the
presence at significantly elevated levels of a circulating soluble form of CTLA-4 in 70% of B-ALL pediatric patients with active
disease, the positive correlation between the percentage of leukemic B lymphocytes and the amount of serum sCTLA-4, and
the expression of sCTLA-4 tra
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