a soluble acetylcholinesterase provides chemical defense against xenobiotics in the pinewood nematode可溶性乙酰胆碱酯酶提供化学防御松木线虫的外源性物质.pdfVIP

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a soluble acetylcholinesterase provides chemical defense against xenobiotics in the pinewood nematode可溶性乙酰胆碱酯酶提供化学防御松木线虫的外源性物质.pdf

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a soluble acetylcholinesterase provides chemical defense against xenobiotics in the pinewood nematode可溶性乙酰胆碱酯酶提供化学防御松木线虫的外源性物质

A Soluble Acetylcholinesterase Provides Chemical Defense against Xenobiotics in the Pinewood Nematode 1 2 2 1,3 Jae Soon Kang , Dae-Weon Lee , Young Ho Koh , Si Hyeock Lee * 1 Research Institute for Agriculture and Life Science, Seoul National University, Seoul, Korea, 2 Ilsong Institute of Life Science, Hallym University, Anyang, Korea, 3 Department of Agricultural Biotechnology, Seoul National University, Seoul, Korea Abstract The pinewood nematode genome encodes at least three distinct acetylcholinesterases (AChEs). To understand physiological roles of the three pinewood nematode AChEs (BxACE-1, BxACE-2, and BxACE-3), BxACE-3 in particular, their tissue distribution and inhibition profiles were investigated. Immunohistochemistry revealed that BxACE-1 and BxACE-2 were distributed in neuronal tissues. In contrast, BxACE-3 was detected from some specific tissues and extracted without the aid of detergent, suggesting its soluble nature unlike BxACE-1 and BxACE-2. When present together, BxAChE3 significantly reduced the inhibition of BxACE-1 and BxACE-2 by cholinesterase inhibitors. Knockdown of BxACE-3 by RNA interference significantly increased the toxicity of three nematicidal compounds, supporting the protective role of BxACE-3 against chemicals. In summary, BxACE-3 appears to have a non-neuronal function of chemical defense whereas both BxACE-1 and BxACE-2 have classical neuronal function of synaptic transmission. Citation: Kang JS, Lee D-W, Koh YH, Lee SH (2011) A Soluble Acetylcholinesterase Provides Chemical Defense against Xenobiotics in the Pinewood Nematode. PLoS ONE 6(4): e19063. doi:10.1371/journal.pone.0019063 Edit