有哪些信誉好的足球投注网站a pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease药理学方法获得囊性纤维化跨膜电导调节功能障碍在吸烟相关的肺部疾病.pdfVIP
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a pharmacologic approach to acquired cystic fibrosis transmembrane conductance regulator dysfunction in smoking related lung disease药理学方法获得囊性纤维化跨膜电导调节功能障碍在吸烟相关的肺部疾病
A Pharmacologic Approach to Acquired Cystic Fibrosis
Transmembrane Conductance Regulator Dysfunction in
Smoking Related Lung Disease
6. 6. 1 1 6 6
Peter A. Sloane , Suresh Shastry , Andrew Wilhelm , Clifford Courville , Li Ping Tang , Kyle Backer ,
6 6 6 6 4 4
Elina Levin , S. Vamsee Raju , Yao Li , Marina Mazur , Suzanne Byan-Parker , William Grizzle ,
Eric J. Sorscher1,3,6, Mark T. Dransfield1,5,6, Steven M. Rowe1,2,3,5,6*
1 Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 2 Department of Pediatrics, University of Alabama at
Birmingham, Birmingham, Alabama, United States of America, 3 Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama,
United States of America, 4 Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 5 UAB Lung Health Center,
University of Alabama at Birmingham, Birmingham, Alabama, United States of America, 6 Cystic Fibrosis Research Center, University of Alabama at Birmingham,
Birmingham, Alabama, United States of America
Abstract
Background: Mucus stasis in chronic obstructive pulmonary disease (COPD) is a significant contributor to morbidity and
mortality. Potentiators of cystic fibrosis transmembrane conductance regulator (CFTR) activity pharmacologically enhance
CFTR function; ivacaftor is one such agent approved to treat CF patients with the G551D-CFTR gating mutation. CFTR
potentiators may also be useful for other diseases of mucus stasis, including COPD.
Methods and Findings: In prim
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