有哪些信誉好的足球投注网站a new drug design targeting the adenosinergic system for huntingtons disease一种新药设计目标为亨廷顿氏舞蹈症adenosinergic系统.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
A New Drug Design Targeting the Adenosinergic System
for Huntington’s Disease
1. 2,3,4. 3 5 4 4
Nai-Kuei Huang , Jung-Hsin Lin , Jiun-Tsai Lin , Chia-I Lin , Eric Minwei Liu , Chun-Jung Lin , Wan-
1 1 3 5 3 5
Ping Chen , Yuh-Chiang Shen , Hui-Mei Chen , Jhih-Bin Chen , Hsing-Lin Lai , Chieh-Wen Yang , Ming-
7 3 3 8 5,6 1
Chang Chiang , Yu-Shuo Wu , Chen Chang , Jiang-Fan Chen , Jim-Min Fang *, Yun-Lian Lin *, Yijuang
Chern3*
1 National Research Institute of Chinese Medicine, Taipei, Taiwan, 2 Division of Mechanics, Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan,
3 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, 4 School of Pharmacy, National Taiwan University, Taipei, Taiwan, 5 Department of Chemistry, National
Taiwan University, Taipei, Taiwan, 6 The Genomics Research Center, Academia Sinica, Taipei, Taiwan, 7 Graduate Institute of Biotechnology, Chinese Culture University,
Taipei, Taiwan, 8 Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, United States of America
Abstract
Background: Huntington’s disease (HD) is a neurodegenerative disease caused by a CAG trinucleotide expansion in the
Huntingtin (Htt) gene. The expanded CAG repeats are translated into polyglutamine (polyQ), causing aberrant functions as
well as aggregate formation of mutant Htt. Effective treatments for HD are yet to be developed.
您可能关注的文档
- a high through-put reverse genetic screen identifies two genes involved in remote memory in mice物料通过量高反向遗传屏幕识别两个基因参与远程小鼠的记忆力.pdf
- a heparan-dependent herpesvirus targets the olfactory neuroepithelium for host entryheparan-dependent疱疹病毒目标主机条目的嗅觉神经上皮.pdf
- a high-density genome-wide association screen of sporadic als in us veterans高密度全基因组关联屏幕上零星的als的美国退伍军人.pdf
- a higher-order generalized singular value decomposition for comparison of global mrna expression from multiple organisms高阶广义奇异值分解进行比较,从多个生物全球mrna的表达.pdf
- a high-fat meal, or intraperitoneal administration of a fat emulsion, increases extracellular dopamine in the nucleus accumbens高脂肪餐,或腹腔内的脂肪乳剂,增加细胞外伏隔核中多巴胺.pdf
- a highly pathogenic strain of staphylococcus sciuri caused fatal exudative epidermitis in piglets高致病性的葡萄球菌sciuri小猪的致命渗出性表皮炎引起的.pdf
- a highly intensified art regimen induces long-term viral suppression and restriction of the viral reservoir in a simian aids model高度强化艺术方案引发长期病毒抑制和猴艾滋病的病毒水库模型的限制.pdf
- a highly sensitive assay for monitoring the secretory pathway and er stress一个高度敏感的试验监测分泌通路和er应激.pdf
- a highly sensitive quantitative real-time pcr assay for determination of mutant jak2 exon 12 allele burden一个高度敏感的实时定量pcr试验测定突变jak2外显子12个等位基因的负担.pdf
- a high-resolution view of genome-wide pneumococcal transformation高分辨率的全基因组肺炎球菌转换.pdf
- a new generation of x-ray baggage scanners based on a different physical principle新一代的x射线行李扫描器基于不同的物理原理.pdf
- a new fluorescence-based method identifies protein phosphatases regulating lipid droplet metabolism一种新的荧光技术方法确定蛋白质磷酸酶调节脂滴的新陈代谢.pdf
- a new hammer to crack an old nut interspecific competitive resource capture by plants is regulated by nutrient supply, not climate新锤裂纹旧螺母种间竞争资源获取植物由营养供应,没有气候.pdf
- a new highly conserved antibiotic sensingresistance pathway in firmicutes involves an abc transporter interplaying with a signal transduction system一种新的高度保守的抗生素sensingresistance通路在厚壁菌门包括abc转运蛋白相互作用的信号转导系统.pdf
- a new hydroxylated nonaprenylhydroquinone from the mediterranean marine sponge sarcotragus spinosulus一个新的羟化nonaprenylhydroquinone从地中海海洋海绵sarcotragus spinosulus.pdf
- a new graphical model for proton nmr (de)shielding over a carbon-carbon double bond to replace the shielding cone model质子核磁共振(de)的新图形模型在碳碳双键取代屏蔽屏蔽锥模型.pdf
- a new in vitro strand transfer assay for monitoring bacterial class 1 integron recombinase inti1 activity一种新的体外链转移试验监测细菌1类整合子重组酶inti1活动.pdf
- a new malaria agent in african hominids一个新的疟疾在非洲原始人的代理.pdf
- a new method for non-invasive estimation of human muscle fiber type composition一种新的非侵入性方法估计人类肌肉纤维类型组成.pdf
- a new highly bioactive composite for scaffold applications a feasibility study一个新的具有高度生物活性复合支架应用的可行性研究.pdf
文档评论（0）