a high-fat meal, or intraperitoneal administration of a fat emulsion, increases extracellular dopamine in the nucleus accumbens高脂肪餐,或腹腔内的脂肪乳剂,增加细胞外伏隔核中多巴胺.pdfVIP

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a high-fat meal, or intraperitoneal administration of a fat emulsion, increases extracellular dopamine in the nucleus accumbens高脂肪餐,或腹腔内的脂肪乳剂,增加细胞外伏隔核中多巴胺.pdf

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a high-fat meal, or intraperitoneal administration of a fat emulsion, increases extracellular dopamine in the nucleus accumbens高脂肪餐,或腹腔内的脂肪乳剂,增加细胞外伏隔核中多巴胺

Brain Sci. 2012, 2, 242-253; doi:10.3390/brainsci2020242 OPEN ACCESS brain sciences ISSN 2076-3425 /journal/brainsci/ Article A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens Pedro Rada 1,2, Nicole M. Avena 2,3, Jessica R. Barson 4, Bartley G. Hoebel 2,† and Sarah F. Leibowitz 4,* 1 Laboratory of Behavioral Physiology, School of Medicine, University of Los Andes, Mérida 5101-A, Venezuela; E-Mail: radap@ula.ve 2 Department of Psychology and Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA 3 Department of Psychiatry, College of Medicine, University of Florida, Gainesville, FL 32610, USA; E-Mail: navena@ 4 Laboratory of Behavioral Neurobiology, The Rockefeller University, New York, NY 10065, USA; E-Mail: jbarson@ † Deceased in June 2011. * Author to whom correspondence should be addressed; E-Mail: leibow@; Tel.: +1-212-327-8378; Fax: +1-212-327-8447. Received: 10 April 2012; in revised form: 4 May 2012 / Accepted: 1 June 2012 / Published: 11 June 2012 Abstract: Evidence links dopamine (DA) in the nucleus accumbens (NAc) shell to the ingestion of palatable diets. Less is known, however, about the specific relation of DA to dietary fat and circulating triglycerides (TG), which are stimulated by fat intake and promote overeating. The present experiments tested in Sprague-Dawley rats whether extracellular levels of NAc DA increase in response to acute access to