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a natural human retrovirus efficiently complements vectors based on murine leukemia virus自然的人类逆转录病毒有效补充基于小鼠白血病病毒的向量
A Natural Human Retrovirus Efficiently Complements
Vectors Based on Murine Leukemia Virus
1 1 2¤
Beihua Dong , Robert H. Silverman , Eugene S. Kandel *
1 Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, 2 Department of Molecular Genetics and Virology,
Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
Abstract
Background: Murine Leukemia Virus (MLV) is a rodent gammaretrovirus that serves as the backbone for common gene
delivery tools designed for experimental and therapeutic applications. Recently, an infectious gammaretrovirus designated
XMRV has been identified in prostate cancer patients. The similarity between the MLV and XMRV genomes suggests a
possibility that the two viruses may interact when present in the same cell.
Methodology/Principal Findings: We tested the ability of XMRV to complement replication-deficient MLV vectors upon co-
infection of cultured human cells. We observed that XMRV can facilitate the spread of these vectors from infected to
uninfected cells. This functional complementation occurred without any gross rearrangements in the vector structure, and
the co-infected cells produced as many as 104 infectious vector particles per milliliter of culture medium.
Conclusions/Significance: The possibility of encountering a helper virus when delivering MLV-based vectors to human cells
in vitro and in vivo needs to be considered to ensure the safety of such procedures.
Citation: Dong B, Silverman RH, Kandel ES (2008) A Natural Human Retrovirus Efficiently Complements Vectors Based on Murine Leukemia Virus. PLoS O
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