a nested case-control study of intrauterine exposure to persistent organochlorine pollutants in relation to risk of type 1 diabetes的嵌套病例对照研究宫内暴露于持久性有机氯污染物与1型糖尿病的风险.pdfVIP

A Nested Case-Control Study of Intrauterine Exposure to Persistent Organochlorine Pollutants in Relation to Risk of Type 1 Diabetes 1 2 3 1 ¨ 1 Anna Rignell-Hydbom *, Maria Elfving , Sten A. Ivarsson , Christian Lindh , Bo A. G. Jonsson , Per Olofsson4, Lars Rylander1 1 Division of Occupational and Environmental Medicine, Lund University, Lund, Sweden, 2 Department of Pediatrics, Lund University Hospital, Lund University, Lund, ¨ ¨ Sweden, 3 Department of Clinical Sciences, Unit of Pediatric Endocrinology, Lund University/CRC, Malmo, Sweden, 4 Department of Obstetrics and Gynecology, Malmo ¨ University Hospital, Lund University, Malmo, Sweden Abstract Background: The incidence of type 1 diabetes in Europe is increasing at a rate of about 3% per year and there is also an increasing incidence throughout the world. Type 1 diabetes is a complex disease caused by multiple genetic and environmental factors. Persistent organochlorine pollutants (POPs) have been suggested as a triggering factor for developing childhood type 1 diabetes. The aim of this case-control study was to assess possible impacts of in utero exposure to POPs on type 1 diabetes. ¨ Methodology/ Principal Findings: The study was performed as a case-control study within a biobank in Malmo, a city located in the