a multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease多价和cross-protective疫苗策略对沙粒病毒与人类疾病有关.pdfVIP

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a multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease多价和cross-protective疫苗策略对沙粒病毒与人类疾病有关.pdf

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a multivalent and cross-protective vaccine strategy against arenaviruses associated with human disease多价和cross-protective疫苗策略对沙粒病毒与人类疾病有关

A Multivalent and Cross-Protective Vaccine Strategy against Arenaviruses Associated with Human Disease 1 2 1 1 1 1 Maya F. Kotturi , Jason Botten , John Sidney , Huynh-Hoa Bui , Lori Giancola , Matt Maybeno , Josie 1 1 1 1 1 3 2 Babin , Carla Oseroff , Valerie Pasquetto , Jason A. Greenbaum , Bjoern Peters , Joey Ting , Danh Do , 4¤ 4¤ 1 3 1 Lo Vang , Jeff Alexander , Howard Grey , Michael J. Buchmeier , Alessandro Sette * 1 Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America, 2 Vermont Center for Immunology and Infectious Diseases, The University of Vermont College of Medicine, Burlington, Vermont, United States of America, 3 Departments of Molecular Biology and Biochemistry and Community and Environmental Medicine, University of California, Irvine, California, United States of America, 4 Pharmexa-Epimmune, San Diego, California, United States of America Abstract Arenaviruses are the causative pathogens of severe hemorrhagic fever and aseptic meningitis in humans, for which no licensed vaccines are currently available. Pathogen heterogeneity within the Arenaviridae family poses a significant challenge for vaccine development. The main hypothesis we tested in the present study was whether it is possible to design a universal vaccine strategy capable of inducing simultaneous HLA-restricted CD8+ T cell responses against 7 pathogenic a