有哪些信誉好的足球投注网站a mycobacterium esx-1–secreted virulence factor with unique requirements for export一个出口esx-1-secreted分枝杆菌毒力因子具有独特的要求.pdfVIP
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a mycobacterium esx-1–secreted virulence factor with unique requirements for export一个出口esx-1-secreted分枝杆菌毒力因子具有独特的要求
A Mycobacterium ESX-1–Secreted
Virulence Factor with Unique
Requirements for Export
1,2 1 2 1¤ 1 2
Bryant McLaughlin , Janet S. Chon , Jason A. MacGurn , Fredric Carlsson , Terri L. Cheng , Jeffery S. Cox ,
Eric J. Brown1,2¤*
1 Program in Microbial Pathogenesis and Host Defense, University of California San Francisco, San Francisco, California, United States of America, 2 Department of
Microbiology and Immunology, University of California San Francisco, San Francisco, California, United States of America
Specialized secretion systems of pathogenic bacteria commonly transport multiple effectors that act in concert to
control and exploit the host cell as a replication-permissive niche. Both the Mycobacterium marinum and the
Mycobacterium tuberculosis genomes contain an extended region of difference 1 (extRD1) locus that encodes one such
pathway, the early secretory antigenic target 6 (ESAT-6) system 1 (ESX-1) secretion apparatus. ESX-1 is required for
virulence and for secretion of the proteins ESAT-6, culture filtrate protein 10 (CFP-10), and EspA. Here, we show that
both Rv3881c and its M. marinum homolog, Mh3881c, are secreted proteins, and disruption of RD1 in either organism
blocks secretion. We have renamed the Rv3881c/Mh3881c gene espB for ESX-1 substrate protein B. Secretion of M.
marinum EspB (EspBM) requires both the Mh3879c and Mh3871 genes within RD1, while CFP-10 secretion is not affected
by disruption of Mh3879c. In contrast, disruption of Mh3866 or Mh3867 within the extRD1 locus prevents CFP-10
secretion without effect on EspBM. Mutants that fail to secrete only EspBM or only CFP-10 are less attenuated in
macrophages than mutants
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