a murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes恶性疟疾的小鼠模型的体内选择主管菌株non-myelodepleted老鼠与人类红细胞的道.pdfVIP
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a murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes恶性疟疾的小鼠模型的体内选择主管菌株non-myelodepleted老鼠与人类红细胞的道
A Murine Model of falciparum-Malaria by In Vivo
Selection of Competent Strains in Non-Myelodepleted
Mice Engrafted with Human Erythrocytes
˜ 1 ´ ´ ´ ´ 1 1 ´ 1
Inigo Angulo-Barturen *, Marıa Belen Jimenez-Dıaz , Teresa Mulet , Joaquın Rullas , Esperanza
1 1 ´ 1 1 2 3
Herreros , Santiago Ferrer , Elena Jimenez , Alfonso Mendoza , Javier Regadera , Philip J. Rosenthal ,
4 5 ´ 1 1
Ian Bathurst , David L. Pompliano , Federico Gomez de las Heras , Domingo Gargallo-Viola
1 Diseases of the Developing World, Infectious Diseases-Centre for Excellence in Drug Discovery (ID CEDD), GlaxoSmithKline, Tres Cantos, Madrid, Spain, 2 Department of
´
Anatomy, Histology and Neuroscience, Faculty of Medicine, Universidad Autonoma de Madrid, Madrid, Spain, 3 Department of Medicine, San Francisco General Hospital,
University of California San Francisco, San Francisco, California, United States of America, 4 Drug Discovery and Technology, Medicines for Malaria Venture (MMV), Geneva,
Switzerland, 5 Infectious Diseases-Centre for Excellence in Drug Discovery (ID CEDD), GlaxoSmithKline, Collegeville, Pennsylvania, United States of America
Abstract
To counter the global threat caused by Plasmodium falciparum malaria, new drugs and vaccines are urgently needed.
Howev
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