有哪些信誉好的足球投注网站a meta-analysis of the existing knowledge of immunoreactivity against hepatitis c virus (hcv)一个荟萃分析的现有知识对丙型肝炎病毒(hcv)的免疫反应性.pdfVIP
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a meta-analysis of the existing knowledge of immunoreactivity against hepatitis c virus (hcv)一个荟萃分析的现有知识对丙型肝炎病毒(hcv)的免疫反应性
A Meta-Analysis of the Existing Knowledge of
Immunoreactivity against Hepatitis C Virus (HCV)
1 1 1 1 2 1
Yohan Kim , Kerrie Vaughan *, Jason Greenbaum , Bjoern Peters , Mansun Law , Alessandro Sette
1The Immune Epitope Database (IEDB), La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America, 2 Department of Immunology and
Microbial Science, The Scripps Research Institute, La Jolla, California, United States of America
Abstract
Approximately 3% of the world population is infected by HCV, which represents a major global health challenge. Almost
400 different scientific reports present immunological data related to T cell and antibody epitopes derived from HCV
literature. Analysis of all HCV-related epitope hosted in the Immune Epitope Database (IEDB), a repository of freely
accessible immune epitope data, revealed more than 1500 and 1900 distinct T cell and antibody epitopes, respectively. The
inventory of all data revealed specific trends in terms of the host and the HCV genotypes from which sequences were
derived. Upon further analysis we found that this large number of epitopes reflects overlapping structures, and homologous
sequences derived from different HCV isolates. To access and visualize this information we developed a novel strategy that
assembles large sets of epitope data, maps them onto reference genomes and displays the frequency of positive responses.
Compilation of the HCV immune reactivity from hundreds of different studies, revealed a complex and thorough picture of
HCV immune epitope data to date. The results pinpoint areas of more intense reactivity or research activities at the level of
antibody, CD4 and CD8 re
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