a meta-analysis reveals the commonalities and differences in arabidopsis thaliana response to different viral pathogens一个荟萃分析揭示了拟南芥的共性和差异应对不同的病毒病原体.pdfVIP

A Meta-Analysis Reveals the Commonalities and Differences in Arabidopsis thaliana Response to Different Viral Pathogens 1. 1,2. 3¤a 4 ´ 4 Guillermo Rodrigo , Javier Carrera , Virgina Ruiz-Ferrer , Francisco J. del Toro , Cesar Llave , Olivier Voinnet3¤b, Santiago F. Elena1,5* ´ ´ ´ ` 1 Instituto de Biologıa Molecular y Celular de Plantas, Consejo Superior de Investigaciones Cientıficas - Universidad Politecnica de Valencia, Valencia, Spain, 2 Instituto ´ ` ´ ITACA, Universidad Politecnica de Valencia, Valencia, Spain, 3 Institut de Biologie Moleculaire des Plantes, CNRS, Strasbourg, France, 4 Centro de Investigaciones ´ Biologicas, CSIC, Madrid, Spain, 5 Santa Fe Institute, Santa Fe, New Mexico, United States of America Abstract Understanding the mechanisms by which plants trigger host defenses in response to viruses has been a challenging problem owing to the multiplicity of factors and complexity of interactions involved. The advent of genomic techniques, however, has opened the possibility to grasp a global picture of the interaction. Here, we used Arabidopsis thaliana to identify and compare genes that are differentially regulated upon infection with seven distinct (+)ssRNA and one ssDNA plant viruses. In the first approach, we established lists of genes differentially affected by each virus and compared their involvement in biological functions and metabolic processes. We found that phylogenetically related viruses s