a kinetic study of accumulation and elimination of microcystin-lr in yellow perch (perca flavescens) tissue and implications for human fish consumption动力学研究的积累和消除美国黄鲈(如蛾)组织和对人工鱼的消费量.pdfVIP

Mar. Drugs 2011, 9, 2553-2571; doi:10.3390/md9122553 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article A Kinetic Study of Accumulation and Elimination of Microcystin-LR in Yellow Perch (Perca Flavescens) Tissue and Implications for Human Fish Consumption Julianne Dyble 1,*, Duane Gossiaux 1, Peter Landrum 1, Donna R. Kashian 2,* and 3 Steven Pothoven 1 NOAA Great Lakes Environmental Research Laboratory, 4840 South State Road, Ann Arbor, MI 48108, USA; E-Mails: duane.gossiaux@ (D.G.); plandrumprof@ (P.L.) 2 Department of Biological Sciences, Wayne State University, 5047 Gullen Mall, Detroit, MI 48202, USA 3 Lake Michigan Field Station, NOAA Great Lakes Environmental Research Laboratory, 1431 Beach Street, Muskegon, MI 49441, USA; E-Mail: steve.pothoven@ * Authors to whom correspondence should be addressed; E-Mails: juli.dyble@ (J.D.); donna.kashian@ (D.R.K.); Tel.: +1-206-860-3393 (J.D.); Fax: +1-206-860-3335 (J.D.). Received: 20 September 2011; in revised form: 15 November 2011 / Accepted: 2 December 2011 / Published: 8 December 2011 Abstract: Fish consumption is a potential route of human exposure to the hepatotoxic microcystins, especially in lakes and reservoirs that routinely experience significant toxic Microcystis blooms. Understanding the rates of uptake and elimination for microcystins as well as the transfer efficiency into tissues of consumers are important for determining the potential for microcystins to be transferred up the food web and f