15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival15-lipoxygenase二十二碳六烯酸的代谢产物抑制前列腺癌的细胞增殖和生存.pdfVIP

下载本文档

1
0
约5.84万字
约 8页
2017-09-07 发布于上海
举报
版权申诉

15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival15-lipoxygenase二十二碳六烯酸的代谢产物抑制前列腺癌的细胞增殖和生存.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

15-lipoxygenase metabolites of docosahexaenoic acid inhibit prostate cancer cell proliferation and survival15-lipoxygenase二十二碳六烯酸的代谢产物抑制前列腺癌的细胞增殖和生存

15-Lipoxygenase Metabolites of Docosahexaenoic Acid Inhibit Prostate Cancer Cell Proliferation and Survival 1 2 3 3 3 Joseph T. O’Flaherty , Yungping Hu , Rhonda E. Wooten , David A. Horita , Michael P. Samuel , 3 2 2 Michael J. Thomas , Haiguo Sun , Iris J. Edwards * 1 Department of Internal Medicine Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America, 2 Department of Pathology, Wake Forest , School of Medicine, Winston-Salem, North Carolina, United States of America, 3 Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America Abstract A 15-LOX, it is proposed, suppresses the growth of prostate cancer in part by converting arachidonic, eicosatrienoic, and/or eicosapentaenoic acids to n-6 hydroxy metabolites. These metabolites inhibit the proliferation of PC3, LNCaP, and DU145 prostate cancer cells but only at $1–10 mM. We show here that the 15-LOX metabolites of docosahexaenoic acid (DHA), 17- hydroperoxy-, 17-hydroxy-, 10,17-dihydroxy-, and 7,17-dihydroxy-DHA inhibit the proliferation of these cells at $0.001, 0.01, 1, and 1 mM, respectively. By comparison, the corresponding 15-hydroperoxy, 15-hydroxy, 8,15-dihydroxy, and 5,15- dihydroxy metabolites of arachidonic acid as well as DHA itself require $10–100 mM to do this. Like DHA, the DHA metabolites a) induce PC3 cells to activate a peroxisome proliferator-activated receptor-c (PPARc) reporter, express syndecan-1, and become apoptotic and b) are b