a history of alcohol dependence increases the incidence and severity of postoperative cognitive dysfunction in cardiac surgical patients酒精依赖的历史会增加术后认知功能障碍的发生率和严重程度在心脏手术的病人.pdfVIP
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a history of alcohol dependence increases the incidence and severity of postoperative cognitive dysfunction in cardiac surgical patients酒精依赖的历史会增加术后认知功能障碍的发生率和严重程度在心脏手术的病人
Int. J. Environ. Res. Public Health 2009, 6, 2725-2739; doi:10.3390/ijerph6112725
OPEN ACCESS
International Journal of
Environmental Research and
Public Health
ISSN 1660-4601
/journal/ijerph
Article
A History of Alcohol Dependence Increases the Incidence and
Severity of Postoperative Cognitive Dysfunction in Cardiac
Surgical Patients
Judith A. Hudetz 1,2,*, Kathleen M. Patterson 2,3, Alison J. Byrne 2, Zafar Iqbal 1,2, Sweeta D.
Gandhi 1,2, David C. Warltier 1,2 and Paul S. Pagel 1,2
1 Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA;
E-Mails: ziqbal@ (Z.I.); sdgandhi@ (S.D.G.); dwarltier@ (D.C.W.);
pspagel@ (P.S.P)
2 Clement J. Zablocki Veterans Administration Medical Center, Milwaukee, WI 53295, USA;
E-Mails: kathleen.patterson@ (K.M.P.); alison.byrne2@ (A.J.B.)
3 Departments of Psychiatry, Behavioral Medicine, and Neurology Medical College of Wisconsin,
Milwaukee, WI 53226, USA
* Author to whom correspondence should be addressed; E-Mail: judith.hudetz@;
Tel.: +1-414-384-2000 Ext: 46856; Fax: +1-414-384-2939.
Received: 27 August 2009 / Accepted: 17 October 2009 / Published: 27 October 2009
Abstract: Postoperative cognitive dysfunction (POCD) commonly occurs after cardiac
surgery. We tested the hypothesis that a history of alcohol dependence is associated with
an increased incidence and severity of POCD in male patients undergoing cardiac sur
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