8,9-epoxyeicosatrienoic acid inhibits antibody production of b lymphocytes in mice8、9-epoxyeicosatrienoic酸能抑制抗体生产的b淋巴细胞在小鼠体内.pdfVIP

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8,9-epoxyeicosatrienoic acid inhibits antibody production of b lymphocytes in mice8、9-epoxyeicosatrienoic酸能抑制抗体生产的b淋巴细胞在小鼠体内.pdf

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8,9-epoxyeicosatrienoic acid inhibits antibody production of b lymphocytes in mice8、9-epoxyeicosatrienoic酸能抑制抗体生产的b淋巴细胞在小鼠体内

8,9-Epoxyeicosatrienoic Acid Inhibits Antibody Production of B Lymphocytes in Mice 1. 1. 1 1 1 2 1 Yanxiang Gao , Juan Feng , Kongyang Ma , Zhou Zhou , Yi Zhu , Qingbo Xu , Xian Wang * 1 Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, People’s Republic of China, 2 Cardiovascular Division, Kings College London BHF Centre, London, United Kingdom Abstract Epoxyeicosatrienoic acids (EETs), synthesized from arachidonic acid by cytochrome P450 epoxygenases, are converted to dihydroxyeicosatrienoic acids by soluble epoxide hydrolase. EETs exert anti-inflammatory effects. However, the effect of EETs on humoral immunity is poorly understood. The present study is to investigate the potential role of EETs on B cell function and mechanisms. We examined the role of EETs on antibody production of splenic B cells from C57BL/6 and apolipoprotein E-deficient (ApoE 2/ 2) mice by means of ELISA. Of the 4 EET regioisomers, 8,9-EET decreased basal and activation-induced B cell antibody secretion. As well, 8,9-EET significantly inhibited B-cell proliferation and survival, plasma cell differentiation and class-switch recombination. Western blot analysis revealed that lipopolysaccharide-induced nuclear translocation of NF-kB could be attenuated by 8,9-EET. Furthermore, germinal center formation was impaired by 8,9-EET in mice in vivo. 8,9-EET may inhibit B-cell function in vitro and in vivo, which suggests a new therapeutic strategy for diseases with excess B cell activation. Citation: Gao Y, Feng J, Ma K, Zhou Z, Zhu Y, et al. (2012) 8,9-Epoxyeicosatrienoic Acid Inhibits Anti