有哪些信誉好的足球投注网站8-chloro-cyclic amp and protein kinase a i-selective cyclic amp analogs inhibit cancer cell growth through different mechanisms8-chloro-cyclic amp和蛋白激酶i-selective环腺苷酸类似物通过不同的机制抑制癌细胞的生长.pdfVIP
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8-chloro-cyclic amp and protein kinase a i-selective cyclic amp analogs inhibit cancer cell growth through different mechanisms8-chloro-cyclic amp和蛋白激酶i-selective环腺苷酸类似物通过不同的机制抑制癌细胞的生长
8-Chloro-Cyclic AMP and Protein Kinase A I-Selective
Cyclic AMP Analogs Inhibit Cancer Cell Growth through
Different Mechanisms
1. 2 .¤ 1. 2 3,4
Simona Lucchi , Davide Calebiro * , Tiziana de Filippis , Elisa S. Grassi , Maria Orietta Borghi , Luca
Persani1,2*
`
1 Laboratory of Endocrine and Metabolic Research, Istituto Auxologico Italiano, Milan, Italy, 2 Dipartimento di Scienze Mediche, Universita degli Studi di Milano, Milan,
`
Italy, 3 Laboratory of Immunology, Istituto Auxologico Italiano, Milan, Italy, 4 Dipartimento di Medicina Interna, Universita degli Studi di Milano, Milan, Italy
Abstract
Cyclic AMP (cAMP) inhibits the proliferation of several tumor cells. We previously reported an antiproliferative effect of PKA
I-selective cAMP analogs (8-PIP-cAMP and 8-HA-cAMP) on two human cancer cell lines of different origin. 8-Cl-cAMP,
another cAMP analog with known antiproliferative properties, has been investigated as a potential anticancer drug. Here,
we compared the antiproliferative effect of 8-Cl-cAMP and the PKA I-selective cAMP analogs in three human cancer cell lines
(ARO, NPA and WRO). 8-Cl-cAMP and the PKA I-selective cAMP analogs had similarly potent antiproliferative effects on the
BRAF-positive ARO and NPA cells, but not on the BRAF-negative WRO cells, in which only 8-Cl-cAMP consistently inhibited
cell growth. While treatment with the PKA I-selective cAMP analogs was associated with growth arrest, 8-Cl-cAMP induced
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