有哪些信誉好的足球投注网站a homolog of fhm2 is involved in modulation of excitatory neurotransmission by serotonin in c. elegans的相同器官fhm2参与调制的兴奋性神经传递5 -羟色胺在秀丽隐杆线虫.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a homolog of fhm2 is involved in modulation of excitatory neurotransmission by serotonin in c. elegans的相同器官fhm2参与调制的兴奋性神经传递5 -羟色胺在秀丽隐杆线虫
A Homolog of FHM2 Is Involved in Modulation of
Excitatory Neurotransmission by Serotonin in C. elegans
1 1 1 3
Elena G. Govorunova , Mustapha Moussaif , Andrey Kullyev , Ken C. Q. Nguyen , Thomas V.
1,2 3 1
McDonald , David H. Hall , Ji Y. Sze *
1 Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, New York, United States of America, 2 Department of Medicine, Albert Einstein
College of Medicine, Bronx, New York, United States of America, 3 Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York, United States of
America
Abstract
+ +
The C. elegans eat-6 gene encodes a Na , K -ATPase a subunit and is a homolog of the familial hemiplegic migraine
candidate gene FHM2. Migraine is the most common neurological disorder linked to serotonergic dysfunction. We sought
to study the pathophysiological mechanisms of migraine and their relation to serotonin (5-HT) signaling using C. elegans as
a genetic model. In C. elegans, exogenous 5-HT inhibits paralysis induced by the acetylcholinesterase inhibitor aldicarb. We
found that the eat-6(ad467) mutation or RNAi of eat-6 increases aldicarb sensitivity and causes complete resistance to 5-HT
treatment, indicating that EAT-6 is a component of the pathway that couples 5-HT signaling and ACh neurotransmission.
While a postsynaptic role of EAT-6 at the bodywall NMJs has been well established, we found that EAT-6 may in addition
regulate presynaptic ACh neurotransmission. We show that eat-6 is expressed in ventral cord ACh motor neurons, and that
cell-specific RNAi of eat-6 in the ACh neurons leads to hypersensitivity to aldicarb. Electron microsco
您可能关注的文档
- 6-(4-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-8-ene-3,5-dione)6 -(4 -(2 - { 2 -[2 -(2-hydroxy-ethoxy)乙氧基)乙氧基的}乙基)10-oxa-4-aza-tricyclo[5.2.1.02 6]dec-8-ene-3 5-dione).pdf
- 5-methyl-4-oxo-4,6-dihydro-3h-pyridazino[4,5-b]carbazole-1-carbaldehyde5-methyl-4-oxo-4,6-dihydro-3h-pyridazino carbazole-1-carbaldehyde(4、5 b).pdf
- 6-shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress6-shogaol人类肝癌细胞发生凋亡展品通过内质网应激体内抗肿瘤活性.pdf
- 6-sulphated chondroitins have a positive influence on axonal regeneration对轴突再生6-sulphated软骨素有积极的影响.pdf
- 6-year periodicity and variable synchronicity in a mass-flowering plant6年周期性和变量同步mass-flowering植物.pdf
- 7-phenyl-3,4,8,9-tetrahydro-2h-pyridazino[1,6-a][1,3,5]triazin-2-imine7-phenyl-3 4 8 9-tetrahydro-2h-pyridazino[1,6](1、3、5)triazin-2-imine.pdf
- 8,9-epoxyeicosatrienoic acid inhibits antibody production of b lymphocytes in mice8、9-epoxyeicosatrienoic酸能抑制抗体生产的b淋巴细胞在小鼠体内.pdf
- 8-chloro-cyclic amp and protein kinase a i-selective cyclic amp analogs inhibit cancer cell growth through different mechanisms8-chloro-cyclic amp和蛋白激酶i-selective环腺苷酸类似物通过不同的机制抑制癌细胞的生长.pdf
- 5-httlpr polymorphism impacts task-evoked and resting-state activities of the amygdala in han chinese5-httlpr多态性影响task-evoked和静止状态汉族杏仁核的活动.pdf
- 8-oxoguanine dna glycosylases one lesion, three subfamilies8-oxoguanine dna糖基化酶损伤,三个亚科.pdf
- a holistic approach to marine eco-systems biology一个整体的海洋生态系统生物学方法.pdf
- a honey bee hexamerin, hex 70a, is likely to play an intranuclear role in developing and mature ovarioles and testioles蜜蜂hexamerin十六进制70,可能会发挥在细胞核内的作用在发展和成熟卵巢管和testioles.pdf
- a host small gtp-binding protein arl8 plays crucial roles in tobamovirus rna replication许多小gtp-binding蛋白质arl8在tobamovirus rna复制中扮演至关重要的角色.pdf
- a human development framework for co2 reductions二氧化碳减排的人类发展框架.pdf
- a human cytomegalovirus-encoded microrna regulates expression of multiple viral genes involved in replication人类cytomegalovirus-encoded微rna调节表达多个病毒基因的复制.pdf
- a human monoclonal antibody with neutralizing activity against highly divergent influenza subtypes人类单克隆抗体中和活动对高度不同的流感病毒亚型.pdf
- a hybrid least squares and principal component analysis algorithm for raman spectroscopy混合最小二乘和拉曼光谱主成分分析算法.pdf
- a hybrid life-cycle assessment of nonrenewable energy and greenhouse-gas emissions of a village-level biomass gasification project in china混合生命周期评估不可再生能源和温室气体排放的村级生物质气化项目在中国.pdf
- a humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic micehumanin导数减少β淀粉样蛋白的积累和改善内存赤字三重转基因老鼠.pdf
- a hybrid thermopneumatic and electrostatic microvalve with integrated position sensing混合热气动和静电microvalve位置传感集成.pdf
文档评论（0）