5-lipoxygenase deficiency impairs innate and adaptive immune responses during fungal infection5-lipoxygenase不足会损害在真菌感染先天和适应性免疫反应.pdfVIP

5-Lipoxygenase Deficiency Impairs Innate and Adaptive Immune Responses during Fungal Infection 1 1 2 ˜ 3 Adriana Secatto , Lilian Cataldi Rodrigues , Carlos Henrique Serezani , Simone Gusmao Ramos , 1 ´ 1 4 Marcelo Dias-Baruffi , Lucia Helena Faccioli , Alexandra I. Medeiros * ´ ´ ´ ´ ˆ ˆ ˜ ˜ ˜ 1 Departamento de Analises Clınicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, ˜ Sao Paulo, Brazil, 2 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, Michigan, United ˜ ˜ ˜ ˜ States of America, 3 Departamento de Patologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil, 4 Departamento ˆ ´ ˆ ˆ ´ ˜ de Ciencias Biologicas, Faculdade de Ciencias Farmaceuticas, Universidade Estadual Paulista ‘‘Julio de Mesquita Filho’’, Araraquara, Sao Paulo, Brazil Abstract 5-lipoxygenase-derived products have been implicated in both the inhibition and promotion of chronic infection. Here, we sought to investigate the roles of endogenous 5-lipoxygenase products and exogenous leukotrienes during Histoplasma capsulatum inf