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5-fu metabolism in cancer and orally-administrable 5-fu drugs研究者用在癌症和orally-administrable研究者用药物代谢
Cancers 2010, 2, 1717-1730; doi:10.3390/cancers2031717
OPEN ACCESS
cancers
ISSN 2072-6694
/journal/cancers
Review
5-FU Metabolism in Cancer and Orally-Administrable
5-FU Drugs
Koh Miura 1,*, Makoto Kinouchi 1, Kazuyuki Ishida 2, Wataru Fujibuchi 3, Takeshi Naitoh 1,
Hitoshi Ogawa 1, Toshinori Ando 1, Nobuki Yazaki 1, Kazuhiro Watanabe 1, Sho Haneda 1,
Chikashi Shibata 1 and Iwao Sasaki 1
1
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan;
E-Mails: kinouchi@surg1.med.tohoku.ac.jp (M.K.); hogawa@surg1.med.tohoku.ac.jp (H.O.);
ando@surg1.med.tohoku.ac.jp (T.A.); n_yazaki@surg1.med.tohoku.ac.jp (N.Y.);
k-wata@surg1.med.tohoku.ac.jp (K.W.); sho@surg1.med.tohoku.ac.jp (S.H.);
cshibata@surg1.med.tohoku.ac.jp (C.S.); isasaki@surg1.med.tohoku.ac.jp (I.S.)
2
Department of Pathology, Tohoku University Hospital, Sendai, Japan;
E-Mail: musubi@patholo2.med.tohoku.ac.jp
3 Computational Biology Research Center, National Institute of Advanced Industrial Science and
Technology, Tokyo, Japan; E-Mail: w.fujibuchi@aist.go.jp
* Author to whom correspondence should be addressed; E-Mail: k-miura@surg1.med.tohoku.ac.jp;
Tel.: +81-22-717-7205; Fax: +81-22-717-7209.
Received: 23 August 2010; in revised form: 14 September 2010 / Accepted: 15 September 2010 /
Published: 17 September 2010
Abstract: 5-Fluorouracil (5-FU) is a key anticancer drug that for its broad antitumor
activity, as well as for its synergism with other anticancer drugs, has been used to treat
various
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